Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis

Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Twelve cohorts analyzed associa...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2022-08, Vol.206 (3), p.321-336
Hauptverfasser:	Lee, Mikyeong, Huan, Tianxiao, McCartney, Daniel L, Chittoor, Geetha, de Vries, Maaike, Lahousse, Lies, Nguyen, Jennifer N, Brody, Jennifer A, Castillo-Fernandez, Juan, Terzikhan, Natalie, Qi, Cancan, Joehanes, Roby, Min, Josine L, Smilnak, Gordon J, Shaw, Jessica R, Yang, Chen Xi, Colicino, Elena, Hoang, Thanh T, Bermingham, Mairead L, Xu, Hanfei, Justice, Anne E, Xu, Cheng-Jian, Rich, Stephen S, Cox, Simon R, Vonk, Judith M, Prokić, Ivana, Sotoodehnia, Nona, Tsai, Pei-Chien, Schwartz, Joel D, Leung, Janice M, Sikdar, Sinjini, Walker, Rosie M, Harris, Sarah E, van der Plaat, Diana A, Van Den Berg, David J, Bartz, Traci M, Spector, Tim D, Vokonas, Pantel S, Marioni, Riccardo E, Taylor, Adele M, Liu, Yongmei, Barr, R Graham, Lange, Leslie A, Baccarelli, Andrea A, Obeidat, Ma'en, Fornage, Myriam, Wang, Tianyuan, Ward, James M, Motsinger-Reif, Alison A, Hemani, Gibran, Koppelman, Gerard H, Bell, Jordana T, Gharib, Sina A, Brusselle, Guy, Boezen, H Marike, North, Kari E, Levy, Daniel, Evans, Kathryn L, Dupuis, Josée, Breeze, Charles E, Manichaikul, Ani, London, Stephanie J
Format:	Artikel
Sprache:	eng
Schlagworte:	CpG Islands DNA methylation DNA Methylation - genetics Epigenesis, Genetic - genetics Epigenetics Epigenome Epigenomics Genome-Wide Association Study Humans Infant, Newborn Lung Lung diseases Meta-analysis Original Pathogenesis Phosphates
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Beschreibung
Zusammenfassung:	Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV , FVC, and FEV /FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. We identified 1,267 CpGs (1,042 genes) differentially methylated (false discovery rate,
ISSN:	1073-449X 1535-4970 1535-4970
DOI:	10.1164/rccm.202108-1907OC