Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening s...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-01, Vol.15 (1), p.e34307 |
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| creator | Molina, Guarina Contreras, Rafael Coombes, Kyle Walgamage, Thilini Perozo, Maria A DesBiens, Martha T |
| description | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome caused by excessive inflammation in the absence of immune regulation. We present the case of a patient with HLH secondary to dysregulated inflammatory response following COVID-19; we also describe the diagnostic and management challenges associated with the condition. |
| doi_str_mv | 10.7759/cureus.34307 |
| format | Article |
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Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome caused by excessive inflammation in the absence of immune regulation. We present the case of a patient with HLH secondary to dysregulated inflammatory response following COVID-19; we also describe the diagnostic and management challenges associated with the condition.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.34307</identifier><identifier>PMID: 36721708</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Allergy/Immunology ; Antibodies ; Biopsy ; Blood ; Bone marrow ; Case reports ; COVID-19 ; Cytokines ; Cytomegalovirus ; Disease ; Fever ; Granulocytes ; Hematology ; Hepatitis A ; HIV ; Human immunodeficiency virus ; Immunoglobulins ; Infections ; Infectious Disease ; Inflammation ; Lymphatic diseases ; Medical diagnosis ; Medical imaging ; Pathophysiology ; Patients ; Pneumonia ; Respiratory syncytial virus ; Severe acute respiratory syndrome coronavirus 2 ; Tomography ; Tuberculosis ; Viral infections</subject><ispartof>Curēus (Palo Alto, CA), 2023-01, Vol.15 (1), p.e34307</ispartof><rights>Copyright © 2023, Molina et al.</rights><rights>Copyright © 2023, Molina et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Molina et al. 2023 Molina et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-ba42b02773955c5ef76a35f650f840db21b18e0920aa1cfa0a378d7b40ff5a3f3</citedby><cites>FETCH-LOGICAL-c309t-ba42b02773955c5ef76a35f650f840db21b18e0920aa1cfa0a378d7b40ff5a3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884115/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884115/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36721708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molina, Guarina</creatorcontrib><creatorcontrib>Contreras, Rafael</creatorcontrib><creatorcontrib>Coombes, Kyle</creatorcontrib><creatorcontrib>Walgamage, Thilini</creatorcontrib><creatorcontrib>Perozo, Maria A</creatorcontrib><creatorcontrib>DesBiens, Martha T</creatorcontrib><title>Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. 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| source | PubMed Central Open Access; PubMed Central |
| subjects | Allergy/Immunology Antibodies Biopsy Blood Bone marrow Case reports COVID-19 Cytokines Cytomegalovirus Disease Fever Granulocytes Hematology Hepatitis A HIV Human immunodeficiency virus Immunoglobulins Infections Infectious Disease Inflammation Lymphatic diseases Medical diagnosis Medical imaging Pathophysiology Patients Pneumonia Respiratory syncytial virus Severe acute respiratory syndrome coronavirus 2 Tomography Tuberculosis Viral infections |
| title | Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection |
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