Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy
Opioid agonists are recommended for opioid use disorder in pregnancy. A large cohort study showed that buprenorphine was associated with lower incidences of neonatal abstinence syndrome and complications at birth than methadone.
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| Veröffentlicht in: | The New England journal of medicine 2022-12, Vol.387 (22), p.2033-2044 |
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| container_issue | 22 |
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| container_title | The New England journal of medicine |
| container_volume | 387 |
| creator | Suarez, Elizabeth A. Huybrechts, Krista F. Straub, Loreen Hernández-Díaz, Sonia Jones, Hendrée E. Connery, Hilary S. Davis, Jonathan M. Gray, Kathryn J. Lester, Barry Terplan, Mishka Mogun, Helen Bateman, Brian T. |
| description | Opioid agonists are recommended for opioid use disorder in pregnancy. A large cohort study showed that buprenorphine was associated with lower incidences of neonatal abstinence syndrome and complications at birth than methadone. |
| doi_str_mv | 10.1056/NEJMoa2203318 |
| format | Article |
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A large cohort study showed that buprenorphine was associated with lower incidences of neonatal abstinence syndrome and complications at birth than methadone.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2203318</identifier><identifier>PMID: 36449419</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Addiction ; Birth weight ; Buprenorphine ; Buprenorphine - adverse effects ; Buprenorphine - therapeutic use ; Cesarean section ; Cesarean Section - statistics & numerical data ; Codes ; Cohort Studies ; Complications of Pregnancy ; Confidence intervals ; Drug abuse ; Drug addiction ; Drug overdose ; Emergency medical care ; Female ; Gestational age ; Gynecology ; Gynecology General ; Hepatitis ; Humans ; Hypothesis testing ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Small for Gestational Age ; Infants ; Live Birth - epidemiology ; Low birth weight ; Medicaid ; Menstruation ; Methadone ; Methadone - adverse effects ; Methadone - therapeutic use ; Narcotics ; Neonatal abstinence syndrome ; Neonates ; Neonatology ; Observational studies ; Obstetrics ; Opiate Substitution Treatment - adverse effects ; Opiate Substitution Treatment - methods ; Opioid-Related Disorders - drug therapy ; Opioid-Related Disorders - epidemiology ; Opioids ; Pediatrics ; Pregnancy ; Pregnancy Complications - drug therapy ; Pregnancy Complications - epidemiology ; Pregnancy Outcome - epidemiology ; Premature birth ; Premature Birth - epidemiology ; Prenatal care ; Psychiatry ; Substance use disorder ; United States - epidemiology</subject><ispartof>The New England journal of medicine, 2022-12, Vol.387 (22), p.2033-2044</ispartof><rights>Copyright © 2022 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2022 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-6741fe8ecc6d180f91406a655b18bb013b646600357fe4a3d0a930015a1760a13</citedby><cites>FETCH-LOGICAL-c445t-6741fe8ecc6d180f91406a655b18bb013b646600357fe4a3d0a930015a1760a13</cites><orcidid>0000-0001-8989-7878</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2203318$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2743551273?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,782,786,887,2761,2762,26110,27931,27932,52389,54071,64392,64396,72476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36449419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suarez, Elizabeth A.</creatorcontrib><creatorcontrib>Huybrechts, Krista F.</creatorcontrib><creatorcontrib>Straub, Loreen</creatorcontrib><creatorcontrib>Hernández-Díaz, Sonia</creatorcontrib><creatorcontrib>Jones, Hendrée E.</creatorcontrib><creatorcontrib>Connery, Hilary S.</creatorcontrib><creatorcontrib>Davis, Jonathan M.</creatorcontrib><creatorcontrib>Gray, Kathryn J.</creatorcontrib><creatorcontrib>Lester, Barry</creatorcontrib><creatorcontrib>Terplan, Mishka</creatorcontrib><creatorcontrib>Mogun, Helen</creatorcontrib><creatorcontrib>Bateman, Brian T.</creatorcontrib><title>Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Opioid agonists are recommended for opioid use disorder in pregnancy. A large cohort study showed that buprenorphine was associated with lower incidences of neonatal abstinence syndrome and complications at birth than methadone.</description><subject>Addiction</subject><subject>Birth weight</subject><subject>Buprenorphine</subject><subject>Buprenorphine - adverse effects</subject><subject>Buprenorphine - therapeutic use</subject><subject>Cesarean section</subject><subject>Cesarean Section - statistics & numerical data</subject><subject>Codes</subject><subject>Cohort Studies</subject><subject>Complications of Pregnancy</subject><subject>Confidence intervals</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Drug overdose</subject><subject>Emergency medical care</subject><subject>Female</subject><subject>Gestational age</subject><subject>Gynecology</subject><subject>Gynecology General</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Hypothesis testing</subject><subject>Infant</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age</subject><subject>Infants</subject><subject>Live Birth - epidemiology</subject><subject>Low birth weight</subject><subject>Medicaid</subject><subject>Menstruation</subject><subject>Methadone</subject><subject>Methadone - adverse effects</subject><subject>Methadone - therapeutic use</subject><subject>Narcotics</subject><subject>Neonatal abstinence syndrome</subject><subject>Neonates</subject><subject>Neonatology</subject><subject>Observational studies</subject><subject>Obstetrics</subject><subject>Opiate Substitution Treatment - adverse effects</subject><subject>Opiate Substitution Treatment - methods</subject><subject>Opioid-Related Disorders - drug therapy</subject><subject>Opioid-Related Disorders - epidemiology</subject><subject>Opioids</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - drug therapy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Premature birth</subject><subject>Premature Birth - epidemiology</subject><subject>Prenatal care</subject><subject>Psychiatry</subject><subject>Substance use disorder</subject><subject>United States - 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A large cohort study showed that buprenorphine was associated with lower incidences of neonatal abstinence syndrome and complications at birth than methadone.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>36449419</pmid><doi>10.1056/NEJMoa2203318</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8989-7878</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2022-12, Vol.387 (22), p.2033-2044 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Addiction Birth weight Buprenorphine Buprenorphine - adverse effects Buprenorphine - therapeutic use Cesarean section Cesarean Section - statistics & numerical data Codes Cohort Studies Complications of Pregnancy Confidence intervals Drug abuse Drug addiction Drug overdose Emergency medical care Female Gestational age Gynecology Gynecology General Hepatitis Humans Hypothesis testing Infant Infant, Low Birth Weight Infant, Newborn Infant, Small for Gestational Age Infants Live Birth - epidemiology Low birth weight Medicaid Menstruation Methadone Methadone - adverse effects Methadone - therapeutic use Narcotics Neonatal abstinence syndrome Neonates Neonatology Observational studies Obstetrics Opiate Substitution Treatment - adverse effects Opiate Substitution Treatment - methods Opioid-Related Disorders - drug therapy Opioid-Related Disorders - epidemiology Opioids Pediatrics Pregnancy Pregnancy Complications - drug therapy Pregnancy Complications - epidemiology Pregnancy Outcome - epidemiology Premature birth Premature Birth - epidemiology Prenatal care Psychiatry Substance use disorder United States - epidemiology |
| title | Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy |
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