Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy

Opioid agonists are recommended for opioid use disorder in pregnancy. A large cohort study showed that buprenorphine was associated with lower incidences of neonatal abstinence syndrome and complications at birth than methadone.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-12, Vol.387 (22), p.2033-2044
Hauptverfasser:	Suarez, Elizabeth A., Huybrechts, Krista F., Straub, Loreen, Hernández-Díaz, Sonia, Jones, Hendrée E., Connery, Hilary S., Davis, Jonathan M., Gray, Kathryn J., Lester, Barry, Terplan, Mishka, Mogun, Helen, Bateman, Brian T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Birth weight Buprenorphine Buprenorphine - adverse effects Buprenorphine - therapeutic use Cesarean section Cesarean Section - statistics & numerical data Codes Cohort Studies Complications of Pregnancy Confidence intervals Drug abuse Drug addiction Drug overdose Emergency medical care Female Gestational age Gynecology Gynecology General Hepatitis Humans Hypothesis testing Infant Infant, Low Birth Weight Infant, Newborn Infant, Small for Gestational Age Infants Live Birth - epidemiology Low birth weight Medicaid Menstruation Methadone Methadone - adverse effects Methadone - therapeutic use Narcotics Neonatal abstinence syndrome Neonates Neonatology Observational studies Obstetrics Opiate Substitution Treatment - adverse effects Opiate Substitution Treatment - methods Opioid-Related Disorders - drug therapy Opioid-Related Disorders - epidemiology Opioids Pediatrics Pregnancy Pregnancy Complications - drug therapy Pregnancy Complications - epidemiology Pregnancy Outcome - epidemiology Premature birth Premature Birth - epidemiology Prenatal care Psychiatry Substance use disorder United States - epidemiology
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Beschreibung
Zusammenfassung:	Opioid agonists are recommended for opioid use disorder in pregnancy. A large cohort study showed that buprenorphine was associated with lower incidences of neonatal abstinence syndrome and complications at birth than methadone.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2203318