Proteomics reveals open reading frames in Mycobacterium tuberculosis H37Rv not predicted by genomics

Genomics revealed the sequence of 3924 genes of the H37Rv strain of Mycobacterium tuberculosis. Proteomics complements genomics in showing which genes are really expressed, and here we show the expression of six genes not predicted by genomics, as proved by two-dimensional electrophoresis and matrix...

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Veröffentlicht in:	Infection and immunity 2001-09, Vol.69 (9), p.5905-5907
Hauptverfasser:	JUNGBLUT, Peter R, MÖLLER, Eva-Christina, MATTOW, Jens, KAUFMANN, Stefan H. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial diseases Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Electrophoresis, Gel, Two-Dimensional Fundamental and applied biological sciences. Psychology Genetics Genome, Bacterial Human bacterial diseases Humans Infectious diseases Medical sciences Microbiology Molecular Pathogenesis Molecular Sequence Data Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Open Reading Frames - genetics Proteome Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tuberculosis and atypical mycobacterial infections
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Beschreibung
Zusammenfassung:	Genomics revealed the sequence of 3924 genes of the H37Rv strain of Mycobacterium tuberculosis. Proteomics complements genomics in showing which genes are really expressed, and here we show the expression of six genes not predicted by genomics, as proved by two-dimensional electrophoresis and matrix-assisted laser desorption ionization and nano-electrospray mass spectrometry.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.69.9.5905-5907.2001