From the dish to humans: A stem cell recipe for success

From the dish to humans: A stem cell recipe for success

Islet transplantation has proven to be an effective treatment for type 1 diabetes (T1D) yet is hampered by the shortage of available tissue. Recently, two reports from a Viacyte multicenter clinical trial demonstrate the feasibility, safety, and potential efficacy of transplanting macro-encapsulated...

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Veröffentlicht in:Cell metabolism 2022-02, Vol.34 (2), p.193-196
Hauptverfasser: Russ, Holger A, Shilleh, Ali H, Sussel, Lori
Format: Artikel
Sprache:eng
Schlagworte:
Cell Differentiation
Diabetes Mellitus, Type 1 - therapy
Endoderm
Humans
Islets of Langerhans Transplantation
Stem Cells
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Zusammenfassung:Islet transplantation has proven to be an effective treatment for type 1 diabetes (T1D) yet is hampered by the shortage of available tissue. Recently, two reports from a Viacyte multicenter clinical trial demonstrate the feasibility, safety, and potential efficacy of transplanting macro-encapsulated human stem cell-derived pancreatic endoderm cells into patients with T1D, highlighting the promise of a stem cell-based therapeutic approach.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2022.01.002