Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn's disease: a quantitative evaluation of patients and non-patients in Japan

Perianal fistula (PF), a complication of Crohn's disease (CD), affects health-related quality of life (QOL). To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. This cross-sectional, observational, web-based questionnaire survey assessed eight...

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Veröffentlicht in:Journal of market access & health policy 2023, Vol.11 (1), p.2166374-2166374
Hauptverfasser: Kato, Masafumi, Yoneyama-Hirozane, Mariko, Iwasaki, Katsuhiko, Matsubayashi, Mao, Igarashi, Ataru
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container_title Journal of market access & health policy
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creator Kato, Masafumi
Yoneyama-Hirozane, Mariko
Iwasaki, Katsuhiko
Matsubayashi, Mao
Igarashi, Ataru
description Perianal fistula (PF), a complication of Crohn's disease (CD), affects health-related quality of life (QOL). To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. This cross-sectional, observational, web-based questionnaire survey assessed eight different health states in patients with CD and PF and individuals without CD (non-patients) from the Medilead Healthcare Panel (MHP) and determined the utility values (QOL scores) in each health state by the time trade-off method. In patients, we determined also the utility value of the current health state associated with CD and the PF. The analysis excluded respondents with logical inconsistencies. The analysis included 82 patients and 576 non-patients with the same sex and age distribution as the Japanese population. In both groups, mean utility values were higher in remission (patients, 0.78; non-patients, 0.51) than in non-remission states, with lowest values for poor prognosis after proctectomy (patients, 0.13; non-patients, −0.10) and highest values for the state with mild symptoms (patients, 0.60; non-patients, 0.30). In patients, the mean utility value of the current health state was 0.71. QOL decreases with increasing severity of PF and is lower for good prognosis after proctostomy than for remission.
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To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. This cross-sectional, observational, web-based questionnaire survey assessed eight different health states in patients with CD and PF and individuals without CD (non-patients) from the Medilead Healthcare Panel (MHP) and determined the utility values (QOL scores) in each health state by the time trade-off method. In patients, we determined also the utility value of the current health state associated with CD and the PF. The analysis excluded respondents with logical inconsistencies. The analysis included 82 patients and 576 non-patients with the same sex and age distribution as the Japanese population. In both groups, mean utility values were higher in remission (patients, 0.78; non-patients, 0.51) than in non-remission states, with lowest values for poor prognosis after proctectomy (patients, 0.13; non-patients, −0.10) and highest values for the state with mild symptoms (patients, 0.60; non-patients, 0.30). In patients, the mean utility value of the current health state was 0.71. QOL decreases with increasing severity of PF and is lower for good prognosis after proctostomy than for remission.</abstract><cop>United States</cop><pub>Routledge</pub><pmid>36684854</pmid><doi>10.1080/20016689.2023.2166374</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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source DOAJ Directory of Open Access Journals; PAIS Index; EBSCOhost Business Source Complete; Access via Taylor & Francis (Open Access Collection); EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Asian cultural groups
Crohn's disease
Disease
Fistula
Health
Japanese
Original
Patients
perianal fistula
Population distribution
Quality of life
Remission (Medicine)
Respondents
time trade-off
utility value
Values
title Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn's disease: a quantitative evaluation of patients and non-patients in Japan
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