Health-related quality of life in health states corresponding to different stages of perianal fistula associated with Crohn's disease: a quantitative evaluation of patients and non-patients in Japan

Perianal fistula (PF), a complication of Crohn's disease (CD), affects health-related quality of life (QOL). To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. This cross-sectional, observational, web-based questionnaire survey assessed eight...

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Veröffentlicht in:Journal of market access & health policy 2023, Vol.11 (1), p.2166374-2166374
Hauptverfasser: Kato, Masafumi, Yoneyama-Hirozane, Mariko, Iwasaki, Katsuhiko, Matsubayashi, Mao, Igarashi, Ataru
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Sprache:eng
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Zusammenfassung:Perianal fistula (PF), a complication of Crohn's disease (CD), affects health-related quality of life (QOL). To elucidate QOL of health states corresponding to different stages of PF associated with CD in Japan. This cross-sectional, observational, web-based questionnaire survey assessed eight different health states in patients with CD and PF and individuals without CD (non-patients) from the Medilead Healthcare Panel (MHP) and determined the utility values (QOL scores) in each health state by the time trade-off method. In patients, we determined also the utility value of the current health state associated with CD and the PF. The analysis excluded respondents with logical inconsistencies. The analysis included 82 patients and 576 non-patients with the same sex and age distribution as the Japanese population. In both groups, mean utility values were higher in remission (patients, 0.78; non-patients, 0.51) than in non-remission states, with lowest values for poor prognosis after proctectomy (patients, 0.13; non-patients, −0.10) and highest values for the state with mild symptoms (patients, 0.60; non-patients, 0.30). In patients, the mean utility value of the current health state was 0.71. QOL decreases with increasing severity of PF and is lower for good prognosis after proctostomy than for remission.
ISSN:2001-6689
2001-6689
DOI:10.1080/20016689.2023.2166374