Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study

The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protei...

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Veröffentlicht in:	Inorganic chemistry 2023-01, Vol.62 (2), p.675-678
Hauptverfasser:	Troisi, Romualdo, Galardo, Francesco, Ferraro, Giarita, Sica, Filomena, Merlino, Antonello
Format:	Artikel
Sprache:	eng
Schlagworte:	Cisplatin - metabolism Communication Humans Iron - chemistry Protein Binding Protein Conformation Receptors, Transferrin - chemistry Receptors, Transferrin - metabolism Transferrin - chemistry
Online-Zugang:	Volltext
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