Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study

Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study

The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protei...

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Veröffentlicht in:Inorganic chemistry 2023-01, Vol.62 (2), p.675-678
Hauptverfasser: Troisi, Romualdo, Galardo, Francesco, Ferraro, Giarita, Sica, Filomena, Merlino, Antonello
Format: Artikel
Sprache:eng
Schlagworte:
Cisplatin - metabolism
Communication
Humans
Iron - chemistry
Protein Binding
Protein Conformation
Receptors, Transferrin - chemistry
Receptors, Transferrin - metabolism
Transferrin - chemistry
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Zusammenfassung:The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation.
ISSN:0020-1669
1520-510X
DOI:10.1021/acs.inorgchem.2c04206