MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2

Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and its pathogenesis is still unclear. The present study aimed to investigate the role of and its downstream target gene, ribonucleotide reductase regulatory subunit M2 ( ), in the occurrence and development of LUAD and elucidate the correlation between and the clinicopathological stage and prognosis of LUAD. The expression of was analyzed using the CancerMIRNome database and quantitative polymerase chain reaction (qPCR). The effects of and on the proliferation, migration, and invasion of A549 cells were analyzed. A dual luciferase reporter assay was used to verify the targeting of and . Additionally, the correlation between expression and clinicopathology was analyzed. (I) was lowly expressed in LUAD and the LUAD cell lines. qPCR confirmed that microRNA (miRNA) transfection was effective and sufficient for subsequent experiments. (II) inhibited the proliferation, invasion, and migration of LUAD cells. (III) There was a targeting relationship between and , and affected the expression of the protein. was highly expressed in lung cancer tissue. (IV) was associated with the clinicopathological staging of lung cancer. The prognosis of patients with low expression was better, and the prognostic sensitivity of to lung cancer was high. may exert its effects via the Notch pathway. (V) Si- inhibited the expression of the protein. promoted the proliferation, migration, and invasion of LUAD cells. A inhibitor restored the inhibitory effect of si- on LUAD cells. was lowly expressed in lung cancer tissue. overexpression inhibited the proliferation and metastasis of lung cancer cells. was highly expressed in lung cancer tissue and promoted the proliferation and metastasis of lung cancer cells. targeted and inhibited , thereby reducing the proliferation and metastasis of LUAD cells. LUAD patients with low expression had a better prognosis, and the expression level of was correlated with the clinical characteristics of lung cancer patients.