Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients

F-FDG PET/MRI might be the diagnostic method of choice for Hodgkin lymphoma patients, as it combines significant metabolic information from PET with excellent soft-tissue contrast from MRI and avoids radiation exposure from CT. However, a major issue is longer examination times than for PET/CT, espe...

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Veröffentlicht in:Journal of Nuclear Medicine 2023-01, Vol.64 (1), p.96-101
Hauptverfasser: Georgi, Thomas W, Stoevesandt, Dietrich, Kurch, Lars, Bartelt, Jörg M, Hasenclever, Dirk, Dittmann, Helmut, Ferda, Jiri, Francis, Peter, Franzius, Christiane, Furth, Christian, Gräfe, Daniel, Gussew, Alexander, Hüllner, Martin, Menezes, Leon J, Mustafa, Mona, Stegger, Lars, Umutlu, Lale, Zöphel, Klaus, Zucchetta, Pietro, Körholz, Dieter, Sabri, Osama, Mauz-Körholz, Christine, Kluge, Regine
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Sprache:eng
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Zusammenfassung:F-FDG PET/MRI might be the diagnostic method of choice for Hodgkin lymphoma patients, as it combines significant metabolic information from PET with excellent soft-tissue contrast from MRI and avoids radiation exposure from CT. However, a major issue is longer examination times than for PET/CT, especially for younger children needing anesthesia. Thus, a targeted selection of suitable whole-body MRI sequences is important to optimize the PET/MRI workflow. The initial PET/MRI scans of 84 EuroNet-PHL-C2 study patients from 13 international PET centers were evaluated. In each available MRI sequence, 5 PET-positive lymph nodes were assessed. If extranodal involvement occurred, 2 splenic lesions, 2 skeletal lesions, and 2 lung lesions were also assessed. A detection rate was calculated dividing the number of visible, anatomically assignable, and measurable lesions in the respective MRI sequence by the total number of lesions. Relaxation time-weighted (T2w) transverse sequences with fat saturation (fs) yielded the best result, with detection rates of 95% for nodal lesions, 62% for splenic lesions, 94% for skeletal lesions, and 83% for lung lesions, followed by T2w transverse sequences without fs (86%, 49%, 16%, and 59%, respectively) and longitudinal relaxation time-weighted contrast-enhanced transverse sequences with fs (74%, 35%, 57%, and 55%, respectively). T2w transverse sequences with fs yielded the highest detection rates and are well suited for accurate whole-body PET/MRI in lymphoma patients. There is no evidence to recommend the use of contrast agents.
ISSN:0161-5505
1535-5667
2159-662X
DOI:10.2967/jnumed.122.264112