Human Mpox (formerly monkeypox): The New Great Imitator?

Since early May 2022, cases of mpox (formerly monkeypox) have been reported in the UK and subsequently in countries where the disease is not endemic. Classic features of the disease include macules, papules, umbilicated vesicles with a necrotic center, as well as pustular and crusting lesions. Nevertheless, new clinical presentations of mpox infection have been identified. Here, Perez-Cavazos and Barragan report the case of a 38-year-old male living with HIV who presented with a clinical course of 4 days of evolution with asthenia, adynamia, fever, and rash. On physical examination, generalized and confluent maculopapular rash predominantly on the back, cervical and inguinal lymphadenopa thies, and Forchheimer's spots were observe. Subsequently, classic mpox pustules appeared. Polymerase chain reaction (PCR) for measles and rubella were negative, and PCR for mpox was positive.