Sequence and antigenic variability of the Helicobacter mustelae surface ring protein Hsr

Sequence and antigenic variability of the Helicobacter mustelae surface ring protein Hsr

We have identified an array of more than 500 repetitive sequences flanking the hsr gene, which encodes the major surface protein of the ferret pathogen Helicobacter mustelae. The repeats show identity exclusively to the amino-terminal half of Hsr. Analysis of Hsr from three strains indicated variabi...

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Veröffentlicht in:Infection and immunity 2001-05, Vol.69 (5), p.3447-3450
Hauptverfasser: FORESTER, Natasha, LUMSDEN, John S, O'CROININ, Tadhg, O'TOOLE, Paul W
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Bacterial Adhesion
Bacterial diseases
Bacterial Proteins - chemistry
Bacterial Proteins - immunology
Bacterial Proteins - physiology
Bacteriology
Biological and medical sciences
Experimental bacterial diseases and models
Ferrets - microbiology
Fundamental and applied biological sciences. Psychology
Genetics
Helicobacter - chemistry
Helicobacter - immunology
Helicobacter mustelae
hsr gene
hsr protein
Infectious diseases
Medical sciences
Microbiology
Molecular Pathogenesis
Molecular Sequence Data
Rabbits
Repetitive Sequences, Amino Acid
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Zusammenfassung:We have identified an array of more than 500 repetitive sequences flanking the hsr gene, which encodes the major surface protein of the ferret pathogen Helicobacter mustelae. The repeats show identity exclusively to the amino-terminal half of Hsr. Analysis of Hsr from three strains indicated variability of exposed epitopes. Characterization of an hsr mutant showed that Hsr is not an adhesin.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.69.5.3447-3450.2001