COVID-19 Causing Infection of Transplanted Lung Allograft: A Pitfall of Prolonged Shedding of SARS-CoV-2 Pre-Transplant

COVID-19 pandemic has led to significant morbidity and mortality across the world. Lung Transplant (LT) is a viable option for a few with COVID-19 related lung disease. Who to transplant and when to transplant, has been the major question impacting the transplant community given the novelty of SARS-...

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Veröffentlicht in:Mayo Clinic proceedings. Innovations, quality & outcomes quality & outcomes, 2023-01
Hauptverfasser: Shah, Sadia Z., Alvarez, Francisco G., Sanghavi, Devang K., Franco-Moreno, Pablo, Isha, Shahin, Marquez, Chris, Libertin, Claudia, Guru, Pramod K., Sareyyupoglu, Basar, Pham, Si M.
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Sprache:eng
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Zusammenfassung:COVID-19 pandemic has led to significant morbidity and mortality across the world. Lung Transplant (LT) is a viable option for a few with COVID-19 related lung disease. Who to transplant and when to transplant, has been the major question impacting the transplant community given the novelty of SARS-CoV-2. We describe a pitfall of presumed prolonged shedding of SARS-CoV-2, in a patient with COVID-19-associated acute respiratory distress syndrome (CARDS), leading to COVID-19 pneumonia post-LT. This raise concerns that replication-competent SARS-CoV-2 virus can persist for months post-infection and can lead to re-infection of allograft in the future.
ISSN:2542-4548
DOI:10.1016/j.mayocpiqo.2023.01.001