Antigiardial Activity of Novel Guanidine Compounds

Antigiardial Activity of Novel Guanidine Compounds

From four focused compound libraries based on the known anticoccidial agent robenidine, 44 compounds total were synthesised and screened for antigiardial activity. All active compounds were counter‐screened for antibiotic and cytotoxic action. Of the analogues examined, 21 displayed IC50

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Veröffentlicht in:ChemMedChem 2022-11, Vol.17 (21), p.e202200341-n/a
Hauptverfasser: Stevens, Andrew J., Abraham, Rebecca, Young, Kelly A., Russell, Cecilia C., McCluskey, Siobhann N., Baker, Jennifer R., Rusdi, Bertha, Page, Stephen W., O'Handley, Ryan, O'Dea, Mark, Abraham, Sam, McCluskey, Adam
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics
Antiparasitic agents
Cytotoxicity
Giardia
Guanidine
Guanidines
Methylene
Metronidazole
Metronidazole - pharmacology
Mice
Regrowth
Robenidine
Toxicity
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Beschreibung
Zusammenfassung:From four focused compound libraries based on the known anticoccidial agent robenidine, 44 compounds total were synthesised and screened for antigiardial activity. All active compounds were counter‐screened for antibiotic and cytotoxic action. Of the analogues examined, 21 displayed IC50
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.202200341