Primary Whole-gland Cryoablation for Prostate Cancer: Biochemical Failure and Clinical Recurrence at 5.6 Years of Follow-up

We retrospectively evaluated complications and functional and oncologic outcomes of 94 consecutive men who underwent primary whole-gland cryoablation for localized prostate cancer (PCa) from 2002 to 2012. Kaplan-Meier and multivariable Cox regression analyses were performed using a landmark starting...

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Veröffentlicht in:	European urology 2019-02, Vol.75 (2), p.208-214
Hauptverfasser:	Oishi, Masakatsu, Gill, Inderbir S., Ashrafi, Akbar N., Lin-Brande, Michael, Nassiri, Nima, Shin, Toshitaka, Bove, Alfredo, Cacciamani, Giovanni E., Ukimura, Osamu, Bahn, Duke K., Abreu, Andre Luis de Castro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biochemical failure Clinical recurrence Cryoablation Cryosurgery - adverse effects Disease Progression Follow-Up Studies Humans Kallikreins - blood Male Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplasm Recurrence, Local Progression-Free Survival Prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Retrospective Studies Risk Factors Time Factors Treatment Failure
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Zusammenfassung:	We retrospectively evaluated complications and functional and oncologic outcomes of 94 consecutive men who underwent primary whole-gland cryoablation for localized prostate cancer (PCa) from 2002 to 2012. Kaplan-Meier and multivariable Cox regression analyses were performed using a landmark starting at 6 mo of follow-up. In total, 75% patients had D’Amico intermediate- (48%) or high- (27%) risk PCa. Median follow-up was 5.6 yr. Median time to prostate-specific antigen (PSA) nadir was 3.3 mo, and 70 patients reached PSA
ISSN:	0302-2838 1873-7560
DOI:	10.1016/j.eururo.2018.09.004