Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

Highlights ► Evidence suggests involvement of pro-inflammatory cytokines in neurodegeneration. ► Pro-inflammatory cytokines are released from activated microglia. ► Cytokines may promote neuronal survival or death depending on environment. ► Microglial cytokine release is a viable target in treatmen...

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Veröffentlicht in:	Brain research bulletin 2012-01, Vol.87 (1), p.10-20
Hauptverfasser:	Smith, Joshua A, Das, Arabinda, Ray, Swapan K, Banik, Naren L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - immunology Humans Inflammation - immunology Inflammation - pathology Interleukin-1 Interleukin-6 Microglia Neurodegeneration Neurodegenerative Diseases - pathology Neurodegenerative Diseases - physiopathology Neurology Pro-inflammatory cytokines Signal Transduction - physiology Sympathetic Nervous System - physiology Tumor necrosis factor-α
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Beschreibung
Zusammenfassung:	Highlights ► Evidence suggests involvement of pro-inflammatory cytokines in neurodegeneration. ► Pro-inflammatory cytokines are released from activated microglia. ► Cytokines may promote neuronal survival or death depending on environment. ► Microglial cytokine release is a viable target in treatment of neurodegeneration.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2011.10.004