Near Infrared Light Induced Radical Polymerization in Water

We introduce a gold nanorod (AuNR) driven methodology to induce free radical polymerization in water with near infrared light (800 nm). The process exploits photothermal conversion in AuNR and subsequent heat transfer to a radical initiator (here azobisisobutyronitrile) for primary radical generation. A broad range of reaction conditions were investigated, demonstrating control over molecular weight and reaction conversion of dimethylacrylamide polymers, using nuclear magnetic resonance spectroscopy. We underpin our experimental data with finite element simulation of the spatio‐temporal temperature profile surrounding the AuNR directly after femtosecond laser pulse excitation. Critically, we evidence that polymerization can be induced through biological tissues given the enhanced penetration depth of the near infrared light. We submit that the presented initiation mechanism in aqueous systems holds promise for radical polymerization in biological environments, including cells. Near infrared irradiation can be sufficient to initiate radical polymerization when absorbed by gold nanorods, exploiting the photothermal effect to transfer energy to a thermal initiator molecule. A water‐soluble monomer is readily polymerized in aqueous environments affording water‐soluble polymers with tuneable molecular weights, including by irradiation through biological tissue.