Probiotic Debaryomyces hansenii CBS 8339 yeast enhanced immune responses in mice

Probiotic Debaryomyces hansenii CBS 8339 yeast enhanced immune responses in mice

This study aimed to examine the effect of Debaryomyces hansenii CBS 8339 on innate immune responses in mice. Thirty BALB/c mice were randomly treated with phosphate buffered saline (PBS) (control) and two D. hansenii (Dh) doses: Dh 10ˆ6 CFU (colony forming units) and Dh 10ˆ8 CFU daily for 15 days. S...

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Veröffentlicht in:3 Biotech 2023-01, Vol.13 (1), p.28-28, Article 28
Hauptverfasser: Angulo, Miriam, Ramos, Abel, Reyes-Becerril, Martha, Guerra, Kevyn, Monreal-Escalante, Elizabeth, Angulo, Carlos
Format: Artikel
Sprache:eng
Schlagworte:
Agriculture
Bioinformatics
Biomaterials
Biotechnology
Blood
Cancer Research
Chemistry
Chemistry and Materials Science
Debaryomyces hansenii
Digestive system
E coli
Gastrointestinal tract
Gene expression
IgG antibody
IL-1β
Immune response
Immunoglobulin A
Immunoglobulin G
Immunology
Inflammation
Innate immunity
Interleukin 6
Nitric oxide
Original
Original Article
Phagocytosis
Probiotics
Respiratory burst
Splenocytes
Stem Cells
Yeast
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Zusammenfassung:This study aimed to examine the effect of Debaryomyces hansenii CBS 8339 on innate immune responses in mice. Thirty BALB/c mice were randomly treated with phosphate buffered saline (PBS) (control) and two D. hansenii (Dh) doses: Dh 10ˆ6 CFU (colony forming units) and Dh 10ˆ8 CFU daily for 15 days. Spleen, blood, and gut samples were taken on days 7 and 15. Mouse splenocytes were isolated and challenged with Escherichia coli . Immunological assays and immune-related gene expressions were performed. Serum was obtained from blood for total IgA and IgG antibody titer determination. Gut samples were taken for yeast colonization assessment. Phagocytosis, respiratory burst activity, and nitric oxide production in mice were mainly enhanced ( p  
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-022-03442-6