Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid‐organ transplant recipients: a retrospective, multicentre cohort study
Background The proportion of Merkel cell carcinomas (MCCs) in solid‐organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. Objective To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV‐sta...
Gespeichert in:
Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2022-11, Vol.36 (11), p.1991-2001 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Background
The proportion of Merkel cell carcinomas (MCCs) in solid‐organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes.
Objective
To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV‐status and identify factors associated with tumour outcomes.
Methods
Retrospective, international, cohort‐study. MCPyV‐status was investigated by immunohistochemistry and polymerase chain reaction.
Results
A total of 30 SOTR and 44 consecutive immunocompetent patients with MCC were enrolled. SOTR were younger at diagnosis (69 vs. 78 years, P |
---|---|
ISSN: | 0926-9959 1468-3083 |
DOI: | 10.1111/jdv.18256 |