Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid‐organ transplant recipients: a retrospective, multicentre cohort study

Background The proportion of Merkel cell carcinomas (MCCs) in solid‐organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. Objective To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV‐sta...

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Veröffentlicht in:Journal of the European Academy of Dermatology and Venereology 2022-11, Vol.36 (11), p.1991-2001
Hauptverfasser: Ferrándiz‐Pulido, C., Gómez‐Tomás, A., Llombart, B., Mendoza, D., Marcoval, J., Piaserico, S., Baykal, C., Bouwes‐Bavinck, J.N., Rácz, E., Kanitakis, J., Harwood, C.A., Cetkovská, P., Geusau, A., Marmol, V., Masferrer, E., Orte Cano, C., Ricar, J., Oliveira, W.R., Salido‐Vallejo, R., Ducroux, E., Gkini, M.A., López‐Guerrero, J.A., Kutzner, H., Kempf, W., Seçkin, D.
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Sprache:eng
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Zusammenfassung:Background The proportion of Merkel cell carcinomas (MCCs) in solid‐organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. Objective To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV‐status and identify factors associated with tumour outcomes. Methods Retrospective, international, cohort‐study. MCPyV‐status was investigated by immunohistochemistry and polymerase chain reaction. Results A total of 30 SOTR and 44 consecutive immunocompetent patients with MCC were enrolled. SOTR were younger at diagnosis (69 vs. 78 years, P 
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.18256