Clinical accuracy of SARS-CoV-2 rapid antigen testing in screening children and adolescents
•SARS-CoV-2 rapid antigen detection tests (RDT) were evaluated among children.•9760 oropharyngeal samples in paediatric patients were enrolled.•RDT sensitivity was 44.7% compared to RT-qPCR.•SARS-CoV-2 virus variant of concern and COVID-19 vaccination status did not have a significant impact of RDT...
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| Veröffentlicht in: | The Journal of infection 2023-03, Vol.86 (3), p.256-308 |
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| container_title | The Journal of infection |
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| creator | Krone, Manuel Wagenhäuser, Isabell Knies, Kerstin Hofmann, Daniela Engels, Geraldine Taurines, Regina McDonogh, Miriam Flemming, Sven Meyer, Thomas Böhm, Hartmut Scherzad, Agmal Eisenmann, Michael Rauschenberger, Vera Gabel, Alexander Petri, Nils Reusch, Julia Forster, Johannes Weißbrich, Benedikt Dölken, Lars Kurzai, Oliver Vogel, Ulrich Härtel, Christoph Liese, Johannes Andres, Oliver |
| description | •SARS-CoV-2 rapid antigen detection tests (RDT) were evaluated among children.•9760 oropharyngeal samples in paediatric patients were enrolled.•RDT sensitivity was 44.7% compared to RT-qPCR.•SARS-CoV-2 virus variant of concern and COVID-19 vaccination status did not have a significant impact of RDT sensitivity. |
| doi_str_mv | 10.1016/j.jinf.2022.12.017 |
| format | Article |
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All rights reserved. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c406t-6f5c08b29ca30a569618949dccebbc05d1f002adf182f017f0f381bc44e8e813</cites><orcidid>0000-0003-0873-3631 ; 0000-0002-4651-3544 ; 0000-0003-3977-038X ; 0000-0003-2773-4269</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016344532200740X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36565725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krone, Manuel</creatorcontrib><creatorcontrib>Wagenhäuser, Isabell</creatorcontrib><creatorcontrib>Knies, Kerstin</creatorcontrib><creatorcontrib>Hofmann, Daniela</creatorcontrib><creatorcontrib>Engels, Geraldine</creatorcontrib><creatorcontrib>Taurines, Regina</creatorcontrib><creatorcontrib>McDonogh, Miriam</creatorcontrib><creatorcontrib>Flemming, Sven</creatorcontrib><creatorcontrib>Meyer, Thomas</creatorcontrib><creatorcontrib>Böhm, Hartmut</creatorcontrib><creatorcontrib>Scherzad, Agmal</creatorcontrib><creatorcontrib>Eisenmann, Michael</creatorcontrib><creatorcontrib>Rauschenberger, Vera</creatorcontrib><creatorcontrib>Gabel, Alexander</creatorcontrib><creatorcontrib>Petri, Nils</creatorcontrib><creatorcontrib>Reusch, Julia</creatorcontrib><creatorcontrib>Forster, Johannes</creatorcontrib><creatorcontrib>Weißbrich, Benedikt</creatorcontrib><creatorcontrib>Dölken, Lars</creatorcontrib><creatorcontrib>Kurzai, Oliver</creatorcontrib><creatorcontrib>Vogel, Ulrich</creatorcontrib><creatorcontrib>Härtel, Christoph</creatorcontrib><creatorcontrib>Liese, Johannes</creatorcontrib><creatorcontrib>Andres, Oliver</creatorcontrib><title>Clinical accuracy of SARS-CoV-2 rapid antigen testing in screening children and adolescents</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>•SARS-CoV-2 rapid antigen detection tests (RDT) were evaluated among children.•9760 oropharyngeal samples in paediatric patients were enrolled.•RDT sensitivity was 44.7% compared to RT-qPCR.•SARS-CoV-2 virus variant of concern and COVID-19 vaccination status did not have a significant impact of RDT sensitivity.</description><subject>Adolescent</subject><subject>Antigens, Viral</subject><subject>Child</subject><subject>Children</subject><subject>Clinical performance evaluation</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 vaccination</subject><subject>Humans</subject><subject>Letter to the Editor</subject><subject>Paediatric</subject><subject>PCR</subject><subject>SARS-CoV-2</subject><subject>SARS-CoV-2 antigen rapid diagnostic test</subject><subject>SARS-CoV-2 virus variants of concern</subject><subject>Sensitivity and Specificity</subject><issn>0163-4453</issn><issn>1532-2742</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVpSbZpvkAPxcde7OqPJdtQCmFpm0CgkIRcehDyaLTR4pW2kjeQb1-ZTUN76UmI-c2befMIec9owyhTn7bN1gfXcMp5w3hDWfeKrJgUvOZdy1-TVYFE3bZSnJK3OW8ppYMY1Ak5FUoq2XG5Ij_Xkw8ezFQZgEMy8FRFV91e3NzW63hf8yqZvbeVCbPfYKhmzLMPm8qHKkNCDMsHHvxkU6maUEgbJ8yAYc7vyBtnpoznz-8Zufv29W59WV__-H61vriuoaVqrpWTQPuRD2AENVINivVDO1gAHEeg0jJHKTfWsZ67YtJRJ3o2Qttijz0TZ-TLUXZ_GHdol9HJTHqf_M6kJx2N1_9Wgn_Qm_ioh051fTcUgY_PAin-OhSHeueLg2kyAeMha97JnrFOUFFQfkQhxZwTupcxjOolFL3VSyh6CUUzrsu-penD3wu-tPxJoQCfjwCWKz16TDqDxwBofUKYtY3-f_q_AR1tnwo</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Krone, Manuel</creator><creator>Wagenhäuser, Isabell</creator><creator>Knies, Kerstin</creator><creator>Hofmann, Daniela</creator><creator>Engels, Geraldine</creator><creator>Taurines, Regina</creator><creator>McDonogh, Miriam</creator><creator>Flemming, Sven</creator><creator>Meyer, Thomas</creator><creator>Böhm, Hartmut</creator><creator>Scherzad, Agmal</creator><creator>Eisenmann, Michael</creator><creator>Rauschenberger, Vera</creator><creator>Gabel, Alexander</creator><creator>Petri, Nils</creator><creator>Reusch, Julia</creator><creator>Forster, Johannes</creator><creator>Weißbrich, Benedikt</creator><creator>Dölken, Lars</creator><creator>Kurzai, Oliver</creator><creator>Vogel, Ulrich</creator><creator>Härtel, Christoph</creator><creator>Liese, Johannes</creator><creator>Andres, Oliver</creator><general>Elsevier Ltd</general><general>The British Infection Association. 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| ispartof | The Journal of infection, 2023-03, Vol.86 (3), p.256-308 |
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| subjects | Adolescent Antigens, Viral Child Children Clinical performance evaluation COVID-19 - diagnosis COVID-19 vaccination Humans Letter to the Editor Paediatric PCR SARS-CoV-2 SARS-CoV-2 antigen rapid diagnostic test SARS-CoV-2 virus variants of concern Sensitivity and Specificity |
| title | Clinical accuracy of SARS-CoV-2 rapid antigen testing in screening children and adolescents |
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