Clinical accuracy of SARS-CoV-2 rapid antigen testing in screening children and adolescents

•SARS-CoV-2 rapid antigen detection tests (RDT) were evaluated among children.•9760 oropharyngeal samples in paediatric patients were enrolled.•RDT sensitivity was 44.7% compared to RT-qPCR.•SARS-CoV-2 virus variant of concern and COVID-19 vaccination status did not have a significant impact of RDT...

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Veröffentlicht in:	The Journal of infection 2023-03, Vol.86 (3), p.256-308
Hauptverfasser:	Krone, Manuel, Wagenhäuser, Isabell, Knies, Kerstin, Hofmann, Daniela, Engels, Geraldine, Taurines, Regina, McDonogh, Miriam, Flemming, Sven, Meyer, Thomas, Böhm, Hartmut, Scherzad, Agmal, Eisenmann, Michael, Rauschenberger, Vera, Gabel, Alexander, Petri, Nils, Reusch, Julia, Forster, Johannes, Weißbrich, Benedikt, Dölken, Lars, Kurzai, Oliver, Vogel, Ulrich, Härtel, Christoph, Liese, Johannes, Andres, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antigens, Viral Child Children Clinical performance evaluation COVID-19 - diagnosis COVID-19 vaccination Humans Letter to the Editor Paediatric PCR SARS-CoV-2 SARS-CoV-2 antigen rapid diagnostic test SARS-CoV-2 virus variants of concern Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	•SARS-CoV-2 rapid antigen detection tests (RDT) were evaluated among children.•9760 oropharyngeal samples in paediatric patients were enrolled.•RDT sensitivity was 44.7% compared to RT-qPCR.•SARS-CoV-2 virus variant of concern and COVID-19 vaccination status did not have a significant impact of RDT sensitivity.
ISSN:	0163-4453 1532-2742 1532-2742
DOI:	10.1016/j.jinf.2022.12.017