Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies,...

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Veröffentlicht in:Nature reviews. Immunology 2023-03, Vol.23 (3), p.135-136
Hauptverfasser: Ju, Yi, Carreño, Juan Manuel, Simon, Viviana, Dawson, Kenneth, Krammer, Florian, Kent, Stephen J.
Format: Artikel
Sprache:eng
Schlagworte:
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Antibodies
Antibodies, Neutralizing
Biomedical and Life Sciences
Biomedicine
Comment
Coronaviruses
COVID-19
COVID-19 Vaccines
Drug dosages
Humans
Immunology
Infectious diseases
Lipids
Medicine
mRNA
mRNA vaccines
Nanoparticles
Polyethylene glycol
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccines
Vaccines, Synthetic
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Beschreibung
Zusammenfassung:The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.
ISSN:1474-1733
1474-1741
1474-1741
DOI:10.1038/s41577-022-00825-x