Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults

Due to its rare incidence, molecular features of primary aldosteronism (PA) in young adults are largely unknown. Recently developed targeted mutational analysis identified aldosterone-driver somatic mutations in aldosterone-producing lesions, including aldosterone-producing adenomas (APAs), aldoster...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2022-09, Vol.107 (9), p.2473-2482
Hauptverfasser:	Nanba, Kazutaka, Baker, Jessica E, Blinder, Amy R, Bick, Nolan R, Liu, Chia-Jen, Lim, Jung Soo, Wachtel, Heather, Cohen, Debbie L, Williams, Tracy Ann, Reincke, Martin, Lyden, Melanie L, Bancos, Irina, Young, William F, Else, Tobias, Giordano, Thomas J, Udager, Aaron M, Rainey, William E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - pathology Adrenal Cortex Neoplasms - pathology Adrenocortical Adenoma - pathology Adult Aldosterone Calcium Channels, L-Type Clinical Corticosteroids Cytochrome P-450 CYP11B2 - genetics Cytochrome P-450 CYP11B2 - metabolism DNA sequencing Formaldehyde G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics Genetic research Humans Hyperaldosteronism Hyperaldosteronism - pathology Immunohistochemistry Mutation Nucleotide sequencing Registered nurses Teenagers Young Adult Youth
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