Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults
Due to its rare incidence, molecular features of primary aldosteronism (PA) in young adults are largely unknown. Recently developed targeted mutational analysis identified aldosterone-driver somatic mutations in aldosterone-producing lesions, including aldosterone-producing adenomas (APAs), aldoster...
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Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2022-09, Vol.107 (9), p.2473-2482 |
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Hauptverfasser: | , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Due to its rare incidence, molecular features of primary aldosteronism (PA) in young adults are largely unknown. Recently developed targeted mutational analysis identified aldosterone-driver somatic mutations in aldosterone-producing lesions, including aldosterone-producing adenomas (APAs), aldosterone-producing nodules (APNs), and aldosterone-producing micronodules, formerly known as aldosterone-producing cell clusters.
To investigate histologic and genetic characteristics of lateralized PA in young adults.
Formalin-fixed, paraffin-embedded adrenal tissue sections from 74 young patients with lateralized PA ( |
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ISSN: | 0021-972X 1945-7197 |
DOI: | 10.1210/clinem/dgac408 |