MRI free water as a biomarker for cognitive performance: Validation in the MarkVCID consortium

Introduction To evaluate the clinical validity of free water (FW), a diffusion tensor imaging–based biomarker kit proposed by the MarkVCID consortium, by investigating the association between mean FW (mFW) and executive function. Methods Baseline mFW was related to a baseline composite measure of ex...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Alzheimer's & dementia : diagnosis, assessment & disease monitoring assessment & disease monitoring, 2022, Vol.14 (1), p.e12362-n/a
Hauptverfasser:	Maillard, Pauline, Hillmer, Laura J., Lu, Hanzhang, Arfanakis, Konstantinos, Gold, Brian T., Bauer, Christopher E., Kramer, Joel H., Staffaroni, Adam M., Stables, Lara, Wang, Danny J.J., Seshadri, Sudha, Satizabal, Claudia L., Beiser, Alexa, Habes, Mohamad, Fornage, Myriam, Mosley, Thomas H., Rosenberg, Gary A., Singh, Baljeet, Singh, Herpreet, Schwab, Kristin, Helmer, Karl G., Greenberg, Steven M., DeCarli, Charles, Caprihan, Arvind
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer's disease Atherosclerosis biomarker Biomarkers Cognition & reasoning Cognitive ability Cohort analysis Colleges & universities Consortia Dementia Diabetes diffusion tensor imaging free water Health sciences Hypertension Magnetic resonance imaging Neurological disorders Older people Reproducibility small vessel disease vascular contributions to cognitive impairment and dementia VCID white matter injury
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Introduction To evaluate the clinical validity of free water (FW), a diffusion tensor imaging–based biomarker kit proposed by the MarkVCID consortium, by investigating the association between mean FW (mFW) and executive function. Methods Baseline mFW was related to a baseline composite measure of executive function (EFC), adjusting for relevant covariates, in three MarkVCID sub‐cohorts, and replicated in five, large, independent legacy cohorts. In addition, we tested whether baseline mFW predicted accelerated EFC score decline (mean follow‐up time: 1.29 years). Results Higher mFW was found to be associated with lower EFC scores in MarkVCID legacy and sub‐cohorts (p‐values
ISSN:	2352-8729 2352-8729
DOI:	10.1002/dad2.12362