Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans

The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and diver...

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Veröffentlicht in:	Infection and immunity 2000-02, Vol.68 (2), p.982-985
Hauptverfasser:	CRUZ, M. C, SIA, R. A. L, OLSON, M, COX, G. M, HEITMAN, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Calcineurin - genetics Calcineurin - physiology Cryptococcus neoformans Cryptococcus neoformans - classification Cryptococcus neoformans - growth & development Cryptococcus neoformans - pathogenicity Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data Mutation Mycology Pathogenicity, host-agent relations, miscellaneous strains, epidemiology Serotyping Virulence
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Beschreibung
Zusammenfassung:	The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.68.2.982-985.2000