Initial Assessment of Boiling Histotripsy for Mechanical Ablation of Ex Vivo Human Prostate Tissue

Boiling histotripsy (BH) is a focused ultrasound technology that uses millisecond-long pulses with shock fronts to induce mechanical tissue ablation. The pulsing scheme and mechanisms of BH differ from those of cavitation cloud histotripsy, which was previously developed for benign prostatic hyperpl...

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Veröffentlicht in:	Ultrasound in medicine & biology 2023-01, Vol.49 (1), p.62-71
Hauptverfasser:	Khokhlova, Vera A., Rosnitskiy, Pavel B., Tsysar, Sergey A., Buravkov, Sergey V., Ponomarchuk, Ekaterina M., Sapozhnikov, Oleg A., Karzova, Maria M., Khokhlova, Tatiana D., Maxwell, Adam D., Wang, Yak-Nam, Kadrev, Alexey V., Chernyaev, Andrey L., Chernikov, Valery P., Okhobotov, Dmitriy A., Kamalov, Armais A., Schade, George R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Boiling histotripsy High-intensity focused ultrasound High-Intensity Focused Ultrasound Ablation - methods Humans Male Prostate Prostate - diagnostic imaging Prostate - surgery
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Zusammenfassung:	Boiling histotripsy (BH) is a focused ultrasound technology that uses millisecond-long pulses with shock fronts to induce mechanical tissue ablation. The pulsing scheme and mechanisms of BH differ from those of cavitation cloud histotripsy, which was previously developed for benign prostatic hyperplasia. The goal of the work described here was to evaluate the feasibility of using BH to ablate fresh ex vivo human prostate tissue as a proof of principle for developing BH for prostate applications. Fresh human prostate samples (N = 24) were obtained via rapid autopsy (
ISSN:	0301-5629 1879-291X
DOI:	10.1016/j.ultrasmedbio.2022.07.014