A convenient catalytic method for preparation of new tetrahydropyrido[2,3- d ]pyrimidines via a cooperative vinylogous anomeric based oxidation

In this study, a novel functionalized metal-organic frameworks MIL-125(Ti)-N(CH PO H ) was designed and synthesized post-modification methodology. Then, MIL-125(Ti)-N(CH PO H ) as a mesoporous catalyst was applied for the synthesis of a wide range of novel tetrahydropyrido[2,3- ]pyrimidines as bioactive candidate compounds by one-pot condensation reaction of 3-(1-methyl-1 -pyrrol-2-yl)-3-oxopropanenitrile, 6-amino-1,3-dimethylpyrimidine-2,4(1 ,3 )-dione and aromatic aldehydes at 100 °C under solvent-free condition. Interestingly, the preparation of tetrahydropyrido[2,3- ]pyrimidine was achieved vinylogous anomeric based oxidation mechanism with a high yield and short reaction time.