Preparation of Patient Doses of [177Lu]Lu-DOTATATE and [177Lu]Lu-PSMA-617 with Carrier Added (CA) and No Carrier Added (NCA) 177Lu

Purpose [ 177 Lu]Lu-DOTATATE and [ 177 Lu]Lu-PSMA-617 used for targeted radionuclide therapy are very often prepared in the hospital radiopharmacy. The preparation parameters vary depending upon the specific activity of the 177 Lu used. The aim of this study was to develop optimized protocols to be used in the nuclear medicine department for the preparation of patient doses of the above radiopharmaceuticals. Method 177 Lu (CA and NCA) were used for radiolabeling DOTATATE and PSMA-617. Parameters studied are 177 Lu of different specific activity and different peptide concentrations and two different buffer systems. Paper and thin layer chromatography systems were used for estimating the radiochemical yield as well as radiochemical purity. Solid-phase extraction was used for the purification of the labeled tracers. Results [ 177 Lu]Lu-DOTATATE was prepared with CA 177 Lu ( n = 13) and NCA 177 Lu ( n = 6). Four batches each of [ 177 Lu]Lu-PSMA-617 were prepared using CA and NCA 177 Lu. Radiochemical yields > 80% and final product with less than