Association of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia

Primary ciliary dyskinesia (PCD), an inherited lung disease, is characterized by abnormal ciliary function leading to progressive bronchiectasis. There is wide variability in respiratory disease severity at birth and later in life. To evaluate the association between neonatal hospital length of stay (neonatal-LOS) and supplemental oxygen duration (SuppO ) with lung function in pediatric PCD. We hypothesized that longer neonatal-LOS and SuppO are associated with worse lung function (i.e., forced expiratory volume in 1 second percent predicted [FEV pp]). We performed a secondary analysis of the Genetic Disorders of Mucociliary Clearance Consortium prospective longitudinal multicenter cohort study. Participants enrolled, during 2006-2011, were