Osteoblast‐specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase‐1 engenders insulin resistance in high‐fat diet fed mice

Supraphysiological levels of the osteoblast‐enriched mineralization regulator ectonucleotide pyrophosphatase or phosphodiesterase‐1 (NPP1) is associated with type 2 diabetes mellitus. We determined the impact of osteoblast‐specific Enpp1 ablation on skeletal structure and metabolic phenotype in mice...

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Veröffentlicht in:	Journal of cellular physiology 2021-06, Vol.236 (6), p.4614-4624
Hauptverfasser:	Roberts, Fiona L., Rashdan, Nabil A., Phadwal, Kanchan, Markby, Greg R., Dillon, Scott, Zoll, Janna, Berger, Julian, Milne, Elspeth, Orriss, Isabel R., Karsenty, Gerard, Le Saux, Olivier, Morton, Nicholas M., Farquharson, Colin, MacRae, Vicky E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Biomarkers - blood Biomedical materials Blood Glucose - metabolism Bone and Bones - enzymology Bone and Bones - pathology bone‐fat interactions Cancellous Bone - enzymology Cancellous Bone - pathology Cells, Cultured Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet Diet, High-Fat - adverse effects Disease Models, Animal Female Femur - enzymology Femur - pathology genetic animal models Glucose Glucose tolerance High fat diet Insulin Insulin - blood Insulin Resistance Male Males matrix mineralization Metabolism Mice Mice, Knockout Mineralization non‐collagenous proteins Osteoblasts Osteoblasts - enzymology Osteoblasts - pathology Osteocalcin Osteocalcin - blood Osteogenesis Phenotypes Phosphodiesterase Phosphoric Diester Hydrolases - deficiency Phosphoric Diester Hydrolases - genetics Pyrophosphatase Pyrophosphatases - deficiency Pyrophosphatases - genetics Sensitizing Sex Factors Skull - enzymology Skull - pathology Tibia - enzymology Tibia - pathology
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Zusammenfassung:	Supraphysiological levels of the osteoblast‐enriched mineralization regulator ectonucleotide pyrophosphatase or phosphodiesterase‐1 (NPP1) is associated with type 2 diabetes mellitus. We determined the impact of osteoblast‐specific Enpp1 ablation on skeletal structure and metabolic phenotype in mice. Female, but not male, 6‐week‐old mice lacking osteoblast NPP1 expression (osteoblast‐specific knockout [KO]) exhibited increased femoral bone volume or total volume (17.50% vs. 11.67%; p
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.30194