Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limiting toxicity (DLT) or all-grade toxicity in diges...

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Veröffentlicht in:	Nutrients 2022-10, Vol.14 (21), p.4448
Hauptverfasser:	Martin, Pierre, Botsen, Damien, Brugel, Mathias, Bertin, Eric, Carlier, Claire, Mahmoudi, Rachid, Slimano, Florian, Perrier, Marine, Bouché, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Antineoplastic Agents - adverse effects Asthenia Asthenia - complications Asthenia - drug therapy Cancer Cancer patients Care and treatment Chemotherapy Cohort analysis Cohort Studies Colorectal cancer Complications and side effects Criteria Digestive system cancer Disease Drug dosages Drug therapy Drugs Female Gastrointestinal Neoplasms - complications Gastrointestinal Neoplasms - drug therapy Geriatrics Grip strength Hand Strength Health aspects Hospitals Humans Male Malnutrition Medical records Multivariate analysis Muscle Strength Muscle weakness Neurotoxicity Observational studies Older people Oncology, Experimental Patients Risk factors Sarcopenia Sarcopenia - complications Women Womens health
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Zusammenfassung:	In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limiting toxicity (DLT) or all-grade toxicity in digestive cancer patients. HGS measurement was performed with a Jamar dynamometer. Dynapenia was defined according to EWGSOP2 criteria (
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu14214448