Review: Influence of 25(OH)D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes

Briefly, 25-hydroxyvitamin D (25(OH)D) plays an essential role in embryogenesis and the course of intra- and postnatal periods and is crucially involved in the functioning of the mother-placenta-fetus system. The low quantity of 25(OH)D during pregnancy can lead to an elevated risk for preeclampsia...

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Veröffentlicht in:	International journal of molecular sciences 2022-10, Vol.23 (21), p.12935
Hauptverfasser:	Karpova, Nataliia, Dmitrenko, Olga, Arshinova, Ekaterina, Nurbekov, Malik
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Blood levels Blood pressure Dietary Supplements Embryogenesis Enzymes Female Fetuses Gene expression Humans Hypertension Hypotheses Infant, Newborn Neonates Oxidative stress Pathology Placenta Pre-Eclampsia Preeclampsia Pregnancy Pregnancy Complications Review Urine Vitamin D Vitamin D Deficiency - complications Womens health
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Zusammenfassung:	Briefly, 25-hydroxyvitamin D (25(OH)D) plays an essential role in embryogenesis and the course of intra- and postnatal periods and is crucially involved in the functioning of the mother-placenta-fetus system. The low quantity of 25(OH)D during pregnancy can lead to an elevated risk for preeclampsia occurrence. Despite the numerous studies on the association of 25(OH)D deficiency and preeclampsia development, the current research on this theme is contradictory. In this review, we summarize and analyze study data on the effects of 25(OH)D deficiency and supplementation on pregnancy, labor, and fetal and neonatal outcomes.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms232112935