Plasma D-dimer levels are correlated with disease severity among hypertensive patients: A comparative cross-sectional study

Plasma D-dimer levels are correlated with disease severity among hypertensive patients: A comparative cross-sectional study

It has been reported that inappropriate acute thrombus formation is the pathophysiological substrate underlying increased risk and severity of target organ damage in hypertension (HTN). However, the relationship between severity of HTN and D-dimer has not been well characterized. The study was aimed...

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Veröffentlicht in:Medicine (Baltimore) 2022-09, Vol.101 (36), p.e30281-e30281
Hauptverfasser: Long, Yanli, Li, Yi, Zhang, Litao, Tao, Liang, Xiao, Hongyan, Li, Ying, Zhou, Chunyou
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Cross-Sectional Studies
Fibrin Fibrinogen Degradation Products - analysis
Humans
Hypertension - complications
Observational Study
Severity of Illness Index
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container_issue 36
container_start_page e30281
container_title Medicine (Baltimore)
container_volume 101
creator Long, Yanli
Li, Yi
Zhang, Litao
Tao, Liang
Xiao, Hongyan
Li, Ying
Zhou, Chunyou
description It has been reported that inappropriate acute thrombus formation is the pathophysiological substrate underlying increased risk and severity of target organ damage in hypertension (HTN). However, the relationship between severity of HTN and D-dimer has not been well characterized. The study was aimed to assess plasma D-dimer level and its correlation with disease severity among hypertensives. A comparative cross-sectional study was conducted at Wuhan Asia Heart Hospital among 100 participants (60 hypertensives and 40 controls). The correlation between variables were determined using correlation coefficients, regression analysis, and also using different parametric and nonparametric tests. We observed higher D-dimer levels among hypertensives compared to the healthy controls (P 
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However, the relationship between severity of HTN and D-dimer has not been well characterized. The study was aimed to assess plasma D-dimer level and its correlation with disease severity among hypertensives. A comparative cross-sectional study was conducted at Wuhan Asia Heart Hospital among 100 participants (60 hypertensives and 40 controls). The correlation between variables were determined using correlation coefficients, regression analysis, and also using different parametric and nonparametric tests. We observed higher D-dimer levels among hypertensives compared to the healthy controls (P &lt; .001). The D-dimer levels were found to be increased significantly with the severity of HTN (P &lt; .001). D-dimer was found to have a diagnostic power of 86.9% in differentiating complicated from uncomplicated HTN at 0.83 mg/L cutoff value. This study suggests that D-dimer level was higher among hypertensives than control groups and it was also increasing significantly with the severity of HTN. This suggests that hypercoagulability of fibrin plays a role in the occurrence of thromboembolic complications of hypertensive patients.</description><identifier>ISSN: 1536-5964</identifier><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000030281</identifier><identifier>PMID: 36086694</identifier><language>eng</language><publisher>United States: Lippincott Williams &amp; Wilkins</publisher><subject>Cross-Sectional Studies ; Fibrin Fibrinogen Degradation Products - analysis ; Humans ; Hypertension - complications ; Observational Study ; Severity of Illness Index</subject><ispartof>Medicine (Baltimore), 2022-09, Vol.101 (36), p.e30281-e30281</ispartof><rights>Lippincott Williams &amp; Wilkins</rights><rights>Copyright © 2022 the Author(s). 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subjects Cross-Sectional Studies
Fibrin Fibrinogen Degradation Products - analysis
Humans
Hypertension - complications
Observational Study
Severity of Illness Index
title Plasma D-dimer levels are correlated with disease severity among hypertensive patients: A comparative cross-sectional study
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