Changes in Distribution of Severe Neurologic Involvement in US Pediatric Inpatients With COVID-19 or Multisystem Inflammatory Syndrome in Children in 2021 vs 2020

IMPORTANCE: In 2020 during the COVID-19 pandemic, neurologic involvement was common in children and adolescents hospitalized in the United States for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related complications. OBJECTIVE: To provide an update on the spectrum of SARS-CoV-2–rela...

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Veröffentlicht in:	Archives of neurology (Chicago) 2023-01, Vol.80 (1), p.91-98
Hauptverfasser:	LaRovere, Kerri L, Poussaint, Tina Y, Young, Cameron C, Newhams, Margaret M, Kucukak, Suden, Irby, Katherine, Kong, Michele, Schwartz, Stephanie P, Walker, Tracie C, Bembea, Melania M, Wellnitz, Kari, Havlin, Kevin M, Cvijanovich, Natalie Z, Hall, Mark W, Fitzgerald, Julie C, Schuster, Jennifer E, Hobbs, Charlotte V, Halasa, Natasha B, Singh, Aalok R, Mack, Elizabeth H, Bradford, Tamara T, Gertz, Shira J, Schwarz, Adam J, Typpo, Katri V, Loftis, Laura L, Giuliano, John S, Horwitz, Steven M, Biagas, Katherine V, Clouser, Katharine N, Rowan, Courtney M, Maddux, Aline B, Soma, Vijaya L, Babbitt, Christopher J, Aguiar, Cassyanne L, Kolmar, Amanda R, Heidemann, Sabrina M, Harvey, Helen, Zambrano, Laura D, Campbell, Angela P, Randolph, Adrienne G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Antibodies Brief Report Central nervous system Child Children Comments Complications Coronaviruses COVID-19 COVID-19 - complications COVID-19 - epidemiology COVID-19 Vaccines Criteria Demyelination Edema Encephalitis Encephalopathy Female Guillain-Barre syndrome Guillain-Barre Syndrome - epidemiology Hospitalization Humans Immunization Infections Inflammation Inpatients Leukoencephalopathy Male Meningitis Multisystem inflammatory syndrome in children Myelitis Nervous system Nervous System Diseases - epidemiology Nervous System Diseases - etiology Neurological complications Online First Pandemics Patients Pediatrics Polymerase chain reaction Public health Respiratory diseases RNA-directed DNA polymerase SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Signs and symptoms Stroke - epidemiology Teenagers United States - epidemiology Vaccination Vaccines Viral diseases
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Zusammenfassung:	IMPORTANCE: In 2020 during the COVID-19 pandemic, neurologic involvement was common in children and adolescents hospitalized in the United States for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related complications. OBJECTIVE: To provide an update on the spectrum of SARS-CoV-2–related neurologic involvement among children and adolescents in 2021. DESIGN, SETTING, AND PARTICIPANTS: Case series investigation of patients reported to public health surveillance hospitalized with SARS-CoV-2–related illness between December 15, 2020, and December 31, 2021, in 55 US hospitals in 31 states with follow-up at hospital discharge. A total of 2253 patients were enrolled during the investigation period. Patients suspected of having multisystem inflammatory syndrome in children (MIS-C) who did not meet criteria (n = 85) were excluded. Patients (
ISSN:	2168-6149 2168-6157
DOI:	10.1001/jamaneurol.2022.3881