Ameliorative effects of supranutritional selenium on TLR‐4‐NF‐kB‐TNF‐α‐mediated hepatic oxidative injury and inflammation in goats fed high concentrate diet

We examined whether surplus dietary selenium (Se) supply could alleviate high concentrate (HC) diet‐induced hepatic oxidative stress (OS) and inflammation. Eighteen young goats were distributed into three groups; were fed low (LC, concentrate: forage; 35: 65), high concentrate (HC, 65: 35), or Se‐su...

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Veröffentlicht in:	Food science & nutrition 2022-11, Vol.10 (11), p.3842-3854
Hauptverfasser:	Shah, Tahmina, Malhi, Moolchand, Kachiwal, Allah Bux, Bhutto, Bachal, Shah, Qurban Ali, Lei, Yan, Soomro, Saeed Ahmed, Soomro, Jamila, Kalhoro, Nazeer Hussain, Gui, Hongbing
Format:	Artikel
Sprache:	eng
Schlagworte:	acute phase response Albumins Amyloid Animals Antioxidants Catalase cytokines Diet Fatty acids Gas chromatography Gene expression Glutathione Glutathione peroxidase Glycoproteins Goats Inflammation Interleukins Lesions Lipopolysaccharides Liver mRNA Original Original Research Oxidative stress Peroxidase Proteins Receptors Selenium Signal transduction Superoxide dismutase Tumor necrosis factor Tumor necrosis factor receptors Tumor necrosis factor-TNF
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Zusammenfassung:	We examined whether surplus dietary selenium (Se) supply could alleviate high concentrate (HC) diet‐induced hepatic oxidative stress (OS) and inflammation. Eighteen young goats were distributed into three groups; were fed low (LC, concentrate: forage; 35: 65), high concentrate (HC, 65: 35), or Se‐supplemented HC (HCSe, 65: 35 + 0.5 mg Se kg−1 diet) diets for 10 weeks. Short chain fatty acids, OS markers and immunoinflammatory genes expressions were assessed through gas chromatograph, kits, and RT‐qPCR, respectively. Compared with LC, HC diet increased (p
ISSN:	2048-7177 2048-7177
DOI:	10.1002/fsn3.2980