Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans

Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans

Nontargeted metabolomics methods have increased potential to identify new disease biomarkers, but assessments of the additive information provided in large human cohorts by these less biased techniques are limited. To diversify our knowledge of diabetes-associated metabolites, we leveraged a method...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2022-11, Vol.71 (11), p.2426-2437
Hauptverfasser: Chen, Zsu-Zsu, Pacheco, Julian Avila, Gao, Yan, Deng, Shuliang, Peterson, Bennet, Shi, Xu, Zheng, Shuning, Tahir, Usman A, Katz, Daniel H, Cruz, Daniel E, Ngo, Debby, Benson, Mark D, Robbins, Jeremy M, Guo, Xiuqing, Del Rocio Sevilla Gonzalez, Magdalena, Manning, Alisa, Correa, Adolfo, Meigs, James B, Taylor, Kent D, Rich, Stephen S, Goodarzi, Mark O, Rotter, Jerome I, Wilson, James G, Clish, Clary B, Gerszten, Robert E
Format: Artikel
Sprache:eng
Schlagworte:
African Americans
Biomarkers
Black or African American
Blood Glucose - metabolism
Diabetes
Diabetes Mellitus
Fasting
Genetics/Genomes/Proteomics/Metabolomics
Humans
Mass spectroscopy
Metabolites
Metabolomics
Metabolomics - methods
Risk factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Nontargeted metabolomics methods have increased potential to identify new disease biomarkers, but assessments of the additive information provided in large human cohorts by these less biased techniques are limited. To diversify our knowledge of diabetes-associated metabolites, we leveraged a method that measures 305 targeted or "known" and 2,342 nontargeted or "unknown" compounds in fasting plasma samples from 2,750 participants (315 incident cases) in the Jackson Heart Study (JHS)-a community cohort of self-identified African Americans-who are underrepresented in omics studies. We found 307 unique compounds (82 known) associated with diabetes after adjusting for age and sex at a false discovery rate of
ISSN:0012-1797
1939-327X
1939-327X
DOI:10.2337/db22-0033