Acetyl-coA Synthetase 2 potentiates macropinocytosis and muscle wasting through metabolic reprogramming in pancreatic cancer

Acetyl-coA Synthetase 2 potentiates macropinocytosis and muscle wasting through metabolic reprogramming in pancreatic cancer

ACSS2 promotes macropinocytosis and muscle wasting through ETV4/ZIP4 mediated metabolic reprogramming, which provides additional nutrients to support tumor growth in pancreatic cancer.

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2022-06, Vol.163 (5), p.1281-1293.e1
Hauptverfasser: Zhou, Zhijun, Ren, Yu, Yang, Jingxuan, Liu, Mingyang, Shi, Xiuhui, Luo, Wenyi, Fung, Kar-Ming, Xu, Chao, Bronze, Michael S., Zhang, Yuqing, Houchen, Courtney W., Li, Min
Format: Artikel
Sprache:eng
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Zusammenfassung:ACSS2 promotes macropinocytosis and muscle wasting through ETV4/ZIP4 mediated metabolic reprogramming, which provides additional nutrients to support tumor growth in pancreatic cancer.
ISSN:0016-5085
1528-0012
DOI:10.1053/j.gastro.2022.06.058