Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis
Abdominal aortic aneurysm (AAA) refers to local abnormal expansion of the abdominal aorta and mostly occurs in elderly men. MicroRNA (miRNA) is single-stranded RNA consisting of 18–25 nucleotides. It plays a key role in posttranscriptional gene expression and in the regulation of human functions and...
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| creator | Liu, Shenrong Liao, Yanfen Liu, Changsong Zhou, Haobin Chen, Gui Lu, Weiling Huang, Zheng |
| description | Abdominal aortic aneurysm (AAA) refers to local abnormal expansion of the abdominal aorta and mostly occurs in elderly men. MicroRNA (miRNA) is single-stranded RNA consisting of 18–25 nucleotides. It plays a key role in posttranscriptional gene expression and in the regulation of human functions and disease development. miRNA exerts its function mainly through the binding of complementary base pairs to the 3′ regulatory region of mRNA transcripts. Therefore, miRNA-related single-nucleotide polymorphisms (miRSNPs) can affect miRNA expression and processing kinetics. miRSNPs can be classified based on their location: miRSNPs within miRNA-producing genes and miRSNPs within miRNA target genes. Increasing evidence indicates that miRSNPs play an important role in the pathogenic kinetics of cardiovascular diseases. The aim of this study was to identify potential miRNAs and integrate them into a miRSNP-based disease-related pathway network, the results of which are of great significance to the interpretation of the potential mechanisms and functions of miRSNPs in the pathogenesis of diseases. |
| doi_str_mv | 10.1155/2022/8776566 |
| format | Article |
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MicroRNA (miRNA) is single-stranded RNA consisting of 18–25 nucleotides. It plays a key role in posttranscriptional gene expression and in the regulation of human functions and disease development. miRNA exerts its function mainly through the binding of complementary base pairs to the 3′ regulatory region of mRNA transcripts. Therefore, miRNA-related single-nucleotide polymorphisms (miRSNPs) can affect miRNA expression and processing kinetics. miRSNPs can be classified based on their location: miRSNPs within miRNA-producing genes and miRSNPs within miRNA target genes. Increasing evidence indicates that miRSNPs play an important role in the pathogenic kinetics of cardiovascular diseases. The aim of this study was to identify potential miRNAs and integrate them into a miRSNP-based disease-related pathway network, the results of which are of great significance to the interpretation of the potential mechanisms and functions of miRSNPs in the pathogenesis of diseases.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2022/8776566</identifier><identifier>PMID: 36275900</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Abdomen ; Aged ; Aortic Aneurysm, Abdominal - genetics ; Aortic aneurysms ; Apoptosis ; Binding sites ; Bioinformatics ; Gene expression ; Genealogy ; Genomes ; Health risk assessment ; Humans ; Hypotheses ; Male ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Pathogenesis ; Polymorphism, Single Nucleotide - genetics ; RNA, Messenger - genetics ; Roles ; Software packages</subject><ispartof>Oxidative medicine and cellular longevity, 2022, Vol.2022, p.8776566-15</ispartof><rights>Copyright © 2022 Shenrong Liu et al.</rights><rights>Copyright © 2022 Shenrong Liu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Shenrong Liu et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-9aee78a8e5b212fcd48b6cc905c1c1243b9e81838b9a86fe708b5b5d2b73a4dc3</citedby><cites>FETCH-LOGICAL-c448t-9aee78a8e5b212fcd48b6cc905c1c1243b9e81838b9a86fe708b5b5d2b73a4dc3</cites><orcidid>0000-0002-0951-8952 ; 0000-0003-4210-9605 ; 0000-0002-8905-3584 ; 0000-0003-0518-4956</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586150/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586150/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4022,27922,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36275900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ali Sheikh, Md Sayed</contributor><contributor>Md Sayed Ali Sheikh</contributor><creatorcontrib>Liu, Shenrong</creatorcontrib><creatorcontrib>Liao, Yanfen</creatorcontrib><creatorcontrib>Liu, Changsong</creatorcontrib><creatorcontrib>Zhou, Haobin</creatorcontrib><creatorcontrib>Chen, Gui</creatorcontrib><creatorcontrib>Lu, Weiling</creatorcontrib><creatorcontrib>Huang, Zheng</creatorcontrib><title>Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Abdominal aortic aneurysm (AAA) refers to local abnormal expansion of the abdominal aorta and mostly occurs in elderly men. MicroRNA (miRNA) is single-stranded RNA consisting of 18–25 nucleotides. It plays a key role in posttranscriptional gene expression and in the regulation of human functions and disease development. miRNA exerts its function mainly through the binding of complementary base pairs to the 3′ regulatory region of mRNA transcripts. Therefore, miRNA-related single-nucleotide polymorphisms (miRSNPs) can affect miRNA expression and processing kinetics. miRSNPs can be classified based on their location: miRSNPs within miRNA-producing genes and miRSNPs within miRNA target genes. Increasing evidence indicates that miRSNPs play an important role in the pathogenic kinetics of cardiovascular diseases. The aim of this study was to identify potential miRNAs and integrate them into a miRSNP-based disease-related pathway network, the results of which are of great significance to the interpretation of the potential mechanisms and functions of miRSNPs in the pathogenesis of diseases.</description><subject>Abdomen</subject><subject>Aged</subject><subject>Aortic Aneurysm, Abdominal - genetics</subject><subject>Aortic aneurysms</subject><subject>Apoptosis</subject><subject>Binding sites</subject><subject>Bioinformatics</subject><subject>Gene expression</subject><subject>Genealogy</subject><subject>Genomes</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Male</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Pathogenesis</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>Roles</subject><subject>Software packages</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc9vFCEYhifGxv7Qm2dD4sXEjgUGZphLk7GxuklTm6pn8sEwu9QZqDDT7cR_XupuN-rBEwSe74U3T5a9JPgdIZyfUEzpiaiqkpflk-yA1IzmuK7Z090e4_3sMMYbjMuCMvIs2y9KWvF0fpD9XLTGjbazGkbrHfIdAjTY6y-XV-jaLKceRh9m1NzbiKxDjWr9YB30qPFhtBo1zkxhjgNScxq8NOPah-8IXIuuYFytYc7fQzQtWrjRLEN6486kGejnaOPzbK-DPpoX2_Uo-3b-4evZp_zi88fFWXORa8bEmNdgTCVAGK4ooZ1umVCl1jXmmmhCWaFqI4gohKpBlJ2psFBc8ZaqqgDW6uIoO93k3k5qMK1OhQP08jbYAcIsPVj5942zK7n0d7LmoiQcp4A324Dgf0wmjnKwUZu-B2f8FCWtqCCME14k9PU_6I2fQir8m6pYMsLqRB1vKB18jMF0u88QLB-sygercms14a_-LLCDHzUm4O0GWFnXwtr-P-4Xwr2rXg</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Liu, Shenrong</creator><creator>Liao, Yanfen</creator><creator>Liu, Changsong</creator><creator>Zhou, Haobin</creator><creator>Chen, Gui</creator><creator>Lu, Weiling</creator><creator>Huang, Zheng</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0951-8952</orcidid><orcidid>https://orcid.org/0000-0003-4210-9605</orcidid><orcidid>https://orcid.org/0000-0002-8905-3584</orcidid><orcidid>https://orcid.org/0000-0003-0518-4956</orcidid></search><sort><creationdate>2022</creationdate><title>Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis</title><author>Liu, Shenrong ; Liao, Yanfen ; Liu, Changsong ; Zhou, Haobin ; Chen, Gui ; Lu, Weiling ; Huang, Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-9aee78a8e5b212fcd48b6cc905c1c1243b9e81838b9a86fe708b5b5d2b73a4dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abdomen</topic><topic>Aged</topic><topic>Aortic Aneurysm, Abdominal - genetics</topic><topic>Aortic aneurysms</topic><topic>Apoptosis</topic><topic>Binding sites</topic><topic>Bioinformatics</topic><topic>Gene expression</topic><topic>Genealogy</topic><topic>Genomes</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Male</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Pathogenesis</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>Roles</topic><topic>Software packages</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Shenrong</creatorcontrib><creatorcontrib>Liao, Yanfen</creatorcontrib><creatorcontrib>Liu, Changsong</creatorcontrib><creatorcontrib>Zhou, Haobin</creatorcontrib><creatorcontrib>Chen, Gui</creatorcontrib><creatorcontrib>Lu, Weiling</creatorcontrib><creatorcontrib>Huang, Zheng</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Shenrong</au><au>Liao, Yanfen</au><au>Liu, Changsong</au><au>Zhou, Haobin</au><au>Chen, Gui</au><au>Lu, Weiling</au><au>Huang, Zheng</au><au>Ali Sheikh, Md Sayed</au><au>Md Sayed Ali Sheikh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><spage>8776566</spage><epage>15</epage><pages>8776566-15</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Abdominal aortic aneurysm (AAA) refers to local abnormal expansion of the abdominal aorta and mostly occurs in elderly men. MicroRNA (miRNA) is single-stranded RNA consisting of 18–25 nucleotides. It plays a key role in posttranscriptional gene expression and in the regulation of human functions and disease development. miRNA exerts its function mainly through the binding of complementary base pairs to the 3′ regulatory region of mRNA transcripts. Therefore, miRNA-related single-nucleotide polymorphisms (miRSNPs) can affect miRNA expression and processing kinetics. miRSNPs can be classified based on their location: miRSNPs within miRNA-producing genes and miRSNPs within miRNA target genes. Increasing evidence indicates that miRSNPs play an important role in the pathogenic kinetics of cardiovascular diseases. The aim of this study was to identify potential miRNAs and integrate them into a miRSNP-based disease-related pathway network, the results of which are of great significance to the interpretation of the potential mechanisms and functions of miRSNPs in the pathogenesis of diseases.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>36275900</pmid><doi>10.1155/2022/8776566</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-0951-8952</orcidid><orcidid>https://orcid.org/0000-0003-4210-9605</orcidid><orcidid>https://orcid.org/0000-0002-8905-3584</orcidid><orcidid>https://orcid.org/0000-0003-0518-4956</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Aged Aortic Aneurysm, Abdominal - genetics Aortic aneurysms Apoptosis Binding sites Bioinformatics Gene expression Genealogy Genomes Health risk assessment Humans Hypotheses Male MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Pathogenesis Polymorphism, Single Nucleotide - genetics RNA, Messenger - genetics Roles Software packages |
| title | Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis |
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