Pentosan polysulfate regulates hepcidin expression in native Mongolian horses

Pentosan polysulfate regulates hepcidin expression in native Mongolian horses

The aim of this study was to investigate the anti-hepcidin effect of pentosan polysulfate (PPS) in Mongolian horses. Twenty-six healthy horses were randomly allocated in to two-groups; one group was treated with a PPS once a week for 4-weeks while another group keeping as placebo. Blood samples at d...

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Veröffentlicht in:Journal of Veterinary Medical Science 2022, Vol.84(10), pp.1437-1441
Hauptverfasser: WIJEKOON, Suranji, TSOGBADRAKH, Mijiddorj, SUNAGA, Takafumi, WANG, Yanlin, MWALE, Carol, KIM, Sangho, ALIMAA, Damdinsuren, OKUMURA, Masahiro
Format: Artikel
Sprache:eng
Schlagworte:
Hepcidin
horse
Iron
Pentosan polysulfate
Placebos
Surgery
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Zusammenfassung:The aim of this study was to investigate the anti-hepcidin effect of pentosan polysulfate (PPS) in Mongolian horses. Twenty-six healthy horses were randomly allocated in to two-groups; one group was treated with a PPS once a week for 4-weeks while another group keeping as placebo. Blood samples at day 0 (D0), before race (BR; day 28) and after race (AR; day 28) were analyzed for serum biochemistry, hepcidin and iron concentrations. Significant reduction of hepcidin was observed at AR in PPS group when compared with BR placebo (P
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.22-0113