Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors

The proteasome is a promising target for antimalarial chemotherapy. We assessed susceptibilities of fresh Plasmodium falciparum isolates from eastern Uganda to seven proteasome inhibitors: two asparagine ethylenediamines, two macrocyclic peptides, and three peptide boronates; five had median IC valu...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2022-10, Vol.66 (10), p.e0081722-e0081722
Hauptverfasser:	Garg, Shreeya, Kreutzfeld, Oriana, Chelebieva, Sevil, Tumwebaze, Patrick K, Byaruhanga, Oswald, Okitwi, Martin, Orena, Stephen, Katairo, Thomas, Nsobya, Samuel L, Conrad, Melissa D, Aydemir, Ozkan, Legac, Jennifer, Gould, Alexandra E, Bayles, Brett R, Bailey, Jeffrey A, Duffey, Maelle, Lin, Gang, Kirkman, Laura A, Cooper, Roland A, Rosenthal, Philip J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemistry Antimalarials - pharmacology Antimicrobial Chemotherapy Asparagine Drug Resistance - genetics Ethylenediamines - pharmacology Humans Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Mechanisms of Resistance Peptides - pharmacology Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Proteasome Endopeptidase Complex - genetics Proteasome Inhibitors - chemistry Proteasome Inhibitors - pharmacology Uganda
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Zusammenfassung:	The proteasome is a promising target for antimalarial chemotherapy. We assessed susceptibilities of fresh Plasmodium falciparum isolates from eastern Uganda to seven proteasome inhibitors: two asparagine ethylenediamines, two macrocyclic peptides, and three peptide boronates; five had median IC values
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.00817-22