Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients

Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients

Obesity is a risk factor for knee osteoarthritis (KOA). Neuromedin U (NMU) and NMU receptors (NMUR1 and NMUR2) are associated with obesity-related disorders and found in mast cells (MCs), which are elevated in osteoarthritis. However, NMU/NMUR expression was not examined in the synovial membrane (SM...

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Veröffentlicht in:International journal of molecular sciences 2022-09, Vol.23 (19), p.11237
Hauptverfasser: Tsukada, Ayumi, Takata, Ken, Takano, Shotaro, Ohashi, Yoshihisa, Mukai, Manabu, Aikawa, Jun, Iwase, Dai, Inoue, Gen, Takaso, Masashi, Uchida, Kentaro
Format: Artikel
Sprache:eng
Schlagworte:
Age
Antigens
Body weight
Dendritic cells
Gene expression
Humans
Inflammation
Mast Cells
Membranes
Neuromedin
Obesity
Obesity - complications
Osteoarthritis
Pathology
Receptors, Neurotransmitter
Rheumatoid arthritis
Risk analysis
Risk factors
Synovial Membrane
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Zusammenfassung:Obesity is a risk factor for knee osteoarthritis (KOA). Neuromedin U (NMU) and NMU receptors (NMUR1 and NMUR2) are associated with obesity-related disorders and found in mast cells (MCs), which are elevated in osteoarthritis. However, NMU/NMUR expression was not examined in the synovial membrane (SM) or synovial MCs of obese osteoarthritis patients. We compared expression of NMU, NMUR1, NMUR2, and the mast cell (MC) marker, CPA3, in the SM of KOA patients categorized as normal weight (NW; BMI < 25 kg/m2, n = 79), overweight (OW; BMI ≥ 25 and
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911237