Sex Differentially Alters Secretion of Brain Extracellular Vesicles During Aging: A Potential Mechanism for Maintaining Brain Homeostasis

Extracellular vesicles (EVs) in the brain play a role in neuronal homeostasis by removing intracellular material and regulating cell-to-cell communication. Given that sex and aging differentially modulate brain networks, we investigated sex-dependent differences in EV levels and content in the brain...

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Veröffentlicht in:Neurochemical research 2022-11, Vol.47 (11), p.3428-3439
Hauptverfasser: Kim, Yohan, Pérez-González, Rocío, Miller, Chelsea, Kurz, Michelle, D’Acunzo, Pasquale, Goulbourne, Chris N., Levy, Efrat
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container_end_page 3439
container_issue 11
container_start_page 3428
container_title Neurochemical research
container_volume 47
creator Kim, Yohan
Pérez-González, Rocío
Miller, Chelsea
Kurz, Michelle
D’Acunzo, Pasquale
Goulbourne, Chris N.
Levy, Efrat
description Extracellular vesicles (EVs) in the brain play a role in neuronal homeostasis by removing intracellular material and regulating cell-to-cell communication. Given that sex and aging differentially modulate brain networks, we investigated sex-dependent differences in EV levels and content in the brain during aging. EVs were isolated from the brains of 3, 6, 12, 18, and 24 month-old female and male C57BL/6 J mice, and the levels of different EV species determined. While the number of plasma membrane-derived microvesicles and a subset of late endosomes-derived exosomes increased with age in the brain of female mice, no significant changes were seen in males. Mitochondria-derived mitovesicles in the brain increased during aging in both sexes, a change that may reflect aging-dependent alterations in mitochondrial function. These findings reveal enhanced turnover during aging in female brains, suggesting a mechanism for advantageous successful female brain aging and sex-depending different susceptibility to age-related neurodegenerative diseases.
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source MEDLINE; SpringerLink Journals
subjects Age
Aging
Alzheimer's disease
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain
Brain research
Cell Biology
Cell interactions
Endosomes
Exosomes
Extracellular Vesicles
Female
Females
Gender differences
Homeostasis
Intracellular signalling
Laboratories
Male
Males
Medical research
Mice
Mice, Inbred C57BL
Mitochondria
Nanoparticles
Neurochemistry
Neurodegeneration
Neurodegenerative diseases
Neurology
Neurosciences
Original Paper
Parkinson's disease
Physiology
Proteins
Sex
Sexes
Sucrose
Vesicles
title Sex Differentially Alters Secretion of Brain Extracellular Vesicles During Aging: A Potential Mechanism for Maintaining Brain Homeostasis
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