Sex Differentially Alters Secretion of Brain Extracellular Vesicles During Aging: A Potential Mechanism for Maintaining Brain Homeostasis
Extracellular vesicles (EVs) in the brain play a role in neuronal homeostasis by removing intracellular material and regulating cell-to-cell communication. Given that sex and aging differentially modulate brain networks, we investigated sex-dependent differences in EV levels and content in the brain...
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description | Extracellular vesicles (EVs) in the brain play a role in neuronal homeostasis by removing intracellular material and regulating cell-to-cell communication. Given that sex and aging differentially modulate brain networks, we investigated sex-dependent differences in EV levels and content in the brain during aging. EVs were isolated from the brains of 3, 6, 12, 18, and 24 month-old female and male C57BL/6 J mice, and the levels of different EV species determined. While the number of plasma membrane-derived microvesicles and a subset of late endosomes-derived exosomes increased with age in the brain of female mice, no significant changes were seen in males. Mitochondria-derived mitovesicles in the brain increased during aging in both sexes, a change that may reflect aging-dependent alterations in mitochondrial function. These findings reveal enhanced turnover during aging in female brains, suggesting a mechanism for advantageous successful female brain aging and sex-depending different susceptibility to age-related neurodegenerative diseases. |
doi_str_mv | 10.1007/s11064-022-03701-1 |
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Given that sex and aging differentially modulate brain networks, we investigated sex-dependent differences in EV levels and content in the brain during aging. EVs were isolated from the brains of 3, 6, 12, 18, and 24 month-old female and male C57BL/6 J mice, and the levels of different EV species determined. While the number of plasma membrane-derived microvesicles and a subset of late endosomes-derived exosomes increased with age in the brain of female mice, no significant changes were seen in males. Mitochondria-derived mitovesicles in the brain increased during aging in both sexes, a change that may reflect aging-dependent alterations in mitochondrial function. These findings reveal enhanced turnover during aging in female brains, suggesting a mechanism for advantageous successful female brain aging and sex-depending different susceptibility to age-related neurodegenerative diseases.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-022-03701-1</identifier><identifier>PMID: 35904699</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Age ; Aging ; Alzheimer's disease ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain research ; Cell Biology ; Cell interactions ; Endosomes ; Exosomes ; Extracellular Vesicles ; Female ; Females ; Gender differences ; Homeostasis ; Intracellular signalling ; Laboratories ; Male ; Males ; Medical research ; Mice ; Mice, Inbred C57BL ; Mitochondria ; Nanoparticles ; Neurochemistry ; Neurodegeneration ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Original Paper ; Parkinson's disease ; Physiology ; Proteins ; Sex ; Sexes ; Sucrose ; Vesicles</subject><ispartof>Neurochemical research, 2022-11, Vol.47 (11), p.3428-3439</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Given that sex and aging differentially modulate brain networks, we investigated sex-dependent differences in EV levels and content in the brain during aging. EVs were isolated from the brains of 3, 6, 12, 18, and 24 month-old female and male C57BL/6 J mice, and the levels of different EV species determined. While the number of plasma membrane-derived microvesicles and a subset of late endosomes-derived exosomes increased with age in the brain of female mice, no significant changes were seen in males. Mitochondria-derived mitovesicles in the brain increased during aging in both sexes, a change that may reflect aging-dependent alterations in mitochondrial function. These findings reveal enhanced turnover during aging in female brains, suggesting a mechanism for advantageous successful female brain aging and sex-depending different susceptibility to age-related neurodegenerative diseases.</description><subject>Age</subject><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain research</subject><subject>Cell Biology</subject><subject>Cell interactions</subject><subject>Endosomes</subject><subject>Exosomes</subject><subject>Extracellular Vesicles</subject><subject>Female</subject><subject>Females</subject><subject>Gender differences</subject><subject>Homeostasis</subject><subject>Intracellular signalling</subject><subject>Laboratories</subject><subject>Male</subject><subject>Males</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mitochondria</subject><subject>Nanoparticles</subject><subject>Neurochemistry</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Parkinson's 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Differentially Alters Secretion of Brain Extracellular Vesicles During Aging: A Potential Mechanism for Maintaining Brain Homeostasis</title><author>Kim, Yohan ; Pérez-González, Rocío ; Miller, Chelsea ; Kurz, Michelle ; D’Acunzo, Pasquale ; Goulbourne, Chris N. ; Levy, Efrat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-eac3a0af6946a870720400c0aab3fe78be9067046c5a8502e5c30c0271de6d963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Brain research</topic><topic>Cell Biology</topic><topic>Cell interactions</topic><topic>Endosomes</topic><topic>Exosomes</topic><topic>Extracellular Vesicles</topic><topic>Female</topic><topic>Females</topic><topic>Gender 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subjects | Age Aging Alzheimer's disease Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain Brain research Cell Biology Cell interactions Endosomes Exosomes Extracellular Vesicles Female Females Gender differences Homeostasis Intracellular signalling Laboratories Male Males Medical research Mice Mice, Inbred C57BL Mitochondria Nanoparticles Neurochemistry Neurodegeneration Neurodegenerative diseases Neurology Neurosciences Original Paper Parkinson's disease Physiology Proteins Sex Sexes Sucrose Vesicles |
title | Sex Differentially Alters Secretion of Brain Extracellular Vesicles During Aging: A Potential Mechanism for Maintaining Brain Homeostasis |
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