Circulating immune cells with megakaryocyte signature in response to COVID-19 mRNA vaccination

•Adverse events involving platelets (e.g. ITP and VITT) have been reported after COVID-19 vaccination.•pDC-like cells with megakaryocyte signature expressing spike protein were increased in blood after mRNA-1273 vaccination.•Platelets expressing spike protein also appeared in circulation after the t...

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Veröffentlicht in:	Thrombosis research 2022-12, Vol.220, p.1-4
Hauptverfasser:	Kanaji, Taisuke, Morodomi, Yosuke, Kanaji, Sachiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets COVID-19 - prevention & control COVID-19 vaccination Humans Letter to the Editors-in-Chief Megakaryocytes Megakaryocytes - physiology Plasmacytoid dendritic cells Platelets RNA, Messenger - genetics Thrombocytopenia Vaccination
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Beschreibung
Zusammenfassung:	•Adverse events involving platelets (e.g. ITP and VITT) have been reported after COVID-19 vaccination.•pDC-like cells with megakaryocyte signature expressing spike protein were increased in blood after mRNA-1273 vaccination.•Platelets expressing spike protein also appeared in circulation after the third dose of vaccination.
ISSN:	0049-3848 1879-2472 1879-2472
DOI:	10.1016/j.thromres.2022.10.003