Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization

During morphogenesis, changes in the shapes of individual cells are harnessed to mold an entire tissue. These changes in cell shapes require the coupled remodeling of the plasma membrane and underlying actin cytoskeleton. In this review, we highlight cellularization of the Drosophila embryo as a mod...

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Veröffentlicht in:	Seminars in cell & developmental biology 2023-01, Vol.133, p.107-122
Hauptverfasser:	Sokac, Anna Marie, Biel, Natalie, De Renzis, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Animals Cell Membrane - metabolism Cortical compartments Cytokinesis Drosophila - metabolism Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Embryo, Nonmammalian - metabolism Endocytosis Exocytosis Membrane reservoir Membrane trafficking Morphogenesis Myosin-2 Phosphoinositides
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Zusammenfassung:	During morphogenesis, changes in the shapes of individual cells are harnessed to mold an entire tissue. These changes in cell shapes require the coupled remodeling of the plasma membrane and underlying actin cytoskeleton. In this review, we highlight cellularization of the Drosophila embryo as a model system to uncover principles of how membrane and actin dynamics are co-regulated in space and time to drive morphogenesis.
ISSN:	1084-9521 1096-3634
DOI:	10.1016/j.semcdb.2022.03.028