The sun, cholesterol and Orai1 conspire in melanoma
How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca 2+ influx by Orai1, causing protein O‐GlcNAcylation that promotes transformation to invasive melanoma. Graphical Abstract Recent w...
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| Veröffentlicht in: | The EMBO journal 2022-10, Vol.41 (19), p.e112250-n/a |
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| container_title | The EMBO journal |
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| creator | Chung, Woo Young Muallem, Shmuel |
| description | How does skin cancer become metastatic? A recent study by Gross
et al
(2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca
2+
influx by Orai1, causing protein O‐GlcNAcylation that promotes transformation to invasive melanoma.
Graphical Abstract
Recent work reveals unexpected links between UV radiation, lipid biosynthesis, and Orai1‐mediated Ca
2+
influx promoting skin cancerogenesis and metastasis. |
| doi_str_mv | 10.15252/embj.2022112250 |
| format | Article |
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(2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca
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influx by Orai1, causing protein O‐GlcNAcylation that promotes transformation to invasive melanoma.
Graphical Abstract
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et al
(2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca
2+
influx by Orai1, causing protein O‐GlcNAcylation that promotes transformation to invasive melanoma.
Graphical Abstract
Recent work reveals unexpected links between UV radiation, lipid biosynthesis, and Orai1‐mediated Ca
2+
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2+
influx by Orai1, causing protein O‐GlcNAcylation that promotes transformation to invasive melanoma.
Graphical Abstract
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2+
influx promoting skin cancerogenesis and metastasis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>36043335</pmid><doi>10.15252/embj.2022112250</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-6189-4947</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The EMBO journal, 2022-10, Vol.41 (19), p.e112250-n/a |
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| language | eng |
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| source | Springer Nature OA Free Journals |
| subjects | Biosynthesis Calcium channels Calcium influx Calcium ions Cholesterol EMBO03 EMBO21 EMBO38 Invasiveness Melanoma Metastases News & Views Orai1 protein Skin cancer Ultraviolet radiation Views |
| title | The sun, cholesterol and Orai1 conspire in melanoma |
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