The sun, cholesterol and Orai1 conspire in melanoma

The sun, cholesterol and Orai1 conspire in melanoma

How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca 2+ influx by Orai1, causing protein O‐GlcNAcylation that promotes transformation to invasive melanoma. Graphical Abstract Recent w...

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Veröffentlicht in:The EMBO journal 2022-10, Vol.41 (19), p.e112250-n/a
Hauptverfasser: Chung, Woo Young, Muallem, Shmuel
Format: Artikel
Sprache:eng
Schlagworte:
Biosynthesis
Calcium channels
Calcium influx
Calcium ions
Cholesterol
EMBO03
EMBO21
EMBO38
Invasiveness
Melanoma
Metastases
News & Views
Orai1 protein
Skin cancer
Ultraviolet radiation
Views
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Beschreibung
Zusammenfassung:How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca 2+ influx by Orai1, causing protein O‐GlcNAcylation that promotes transformation to invasive melanoma. Graphical Abstract Recent work reveals unexpected links between UV radiation, lipid biosynthesis, and Orai1‐mediated Ca 2+ influx promoting skin cancerogenesis and metastasis.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2022112250