Growing older with HIV in the Treat‐All Era

[...]geriatric syndromes, such as frailty and falls, are becoming more prevalent in PWH. [...]there is an urgent need to focus on the healthspan of PWH rather than just mortality. The first encompasses outcomes across the lifespan, including among younger and older PWH, and their comorbidities, mental health and the UNAIDS 90-90-90 targets for global HIV control (90% of PWH knowing their HIV status, 90% on ART and 90% virally suppressed) [ 5]. While questions abound regarding the relative impact of HIV and inflammation; ART medication, including drug–drug interactions and polypharmacy; behavioural factors, such as diet, smoking, substance use and physical activity; and environmental or genetic factors; it is clear that multiple causes contribute to the higher rates of comorbidities among PWH compared to those without HIV [ 13–18]. Studying participants with and without HIV in the African Cohort Study, Chang et al. examined the prevalence and risk factors of renal insufficiency, elevated blood pressure, diabetes and dysglycemia [ 19].